Research Technician 1

Updated: 5 months ago
Location: Boston, MASSACHUSETTS


Posted: 14-May-23

Location: Boston, Massachusetts

Salary: Unpaid



Internal Number: 3243041-3499_1683925171

We are seeking a bright and motivated individual for a Research Technician I position in the Perugino Laboratory of the Center for Immunology and Inflammatory Diseases (CIID) at Massachusetts General Hospital. The CIID is a multidisciplinary research center with the goal of discovering new molecular pathways in inflammatory diseases.
Dr. Perugino's laboratory is focused on understanding mechanisms of autoimmunity and immune-mediated fibrosis with the goal of developing avenues for future therapeutic development. Systemic sclerosis (SSc) is one such disease marked by chronic tissue inflammation resulting in fibrosis of the blood vessels, skin, lungs, heart, and intestines. Current treatment options are limited and it remains the most lethal rheumatologic disease. Current aims of the laboratory include:
  • Defining pathogenic B cells at sites of disease.
  • Identifying novel antigens driving the B cell response.
  • Determining if pathologically expanded cytotoxic T cells are self-reactive.
  • Phenotyping defects in regulatory T cells in SSc.

  • In order to pursue these aims, we leverage primary blood and skin samples from patients with SSc evaluated at MGH, as well as a wide variety of research techniques including flow cytometry, BCR/TCR sequencing, single cell sequencing, protein microarrays, and in vitro functional assays. We are looking for a research technician to play an interactive and integral role in these studies.
    Duties will include, but are not exclusive to:
    • participation in general laboratory responsibilities, including ordering and organizing laboratory supplies and ensuring maintenance of equipment
    • molecular biological techniques, including DNA and RNA isolation, PCR, and quantitative PCR
    • isolation and purification of primary cells from human tissues
    • flow cytometry
    Candidates for this position should have a solid background in biology and a strong interest in immunology and molecular biology. This position would be ideal for those candidates interested in gaining significant experience in biomedical research and considering future graduate studies. Candidates interested in a two year or longer commitment are strongly preferred.
    • Bachelor's Degree, with coursework in related fields (such as Immunology and Molecular Biology or Biochemistry) strongly preferred
    • previous laboratory experience is highly preferred, but all techniques will be taught upon joining the lab
    • proficiency with computer software, including Power Point and Excel

    EEO Statement
    Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.

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    About MGH Institute of Health Professions
    MGH Institute of Health Professions, founded by Massachusetts General Hospital in 1977, is an innovative and independent graduate school in Boston that is a member of Partners HealthCare. A progressive leader in developing comprehensive models of health care education, the MGH Institute prepares advanced practice professionals in the fields of nursing, physical therapy, occupational therapy and communication sciences and disorders through a distinctive combination of academic study, clinical practice, and research. More than 1,200 students are enrolled in graduate level and certificate programs, with an increasing number of courses available online. The Institute is accredited by the New England Association of Schools and Colleges (NEASC).
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