Research Specialist - Kingsley Lab

Updated: about 14 hours ago
Location: Stanford, CALIFORNIA
Job Type: FullTime

Primary Work Address: Beckman Center, Stanford, CA, 94305-5323


Current HHMI Employees, click here to apply via your Workday account.

We are currently looking for a highly talented, resourceful Research Specialist to join the laboratory of Dr. David Kingsley at Stanford University. The Kingsley lab uses a combination of genetic and genomic approaches to identify the detailed molecular mechanisms that control evolutionary change in vertebrates, with a focus on five fundamental questions:
1. Are key evolutionary traits controlled by countless genetic differences of small effect, or by a few genetic changes with large effects?
2. What specific genes have changed to produce interesting evolutionary differences seen in nature?
3. What kinds of mutations have occurred in these genes (e.g., dominant or recessive, coding or regulatory, preexisting or de novo)?
4. How predictable is evolution? If you know how evolution has occurred in one population, is it possible to predict the types of genes and mutations that also underlie the same trait in different populations or species?
5. How has evolution produced the unique characteristics, and the common traits and diseases, found in humans?
The lab studies these questions using a variety of genetic and genomic methods in mice, stickleback fish, and human beings. More information about the Kingsley lab can be found here: https://kingsley.stanford.edu/

This is a dynamic position that will contribute broadly to the Kingsley lab’s goals while also managing one’s own independent research projects. The ideal candidate enjoys bench research, has strong interpersonal skills, and has the ability to serve as a trusted resource and mentor for more junior lab team members in a highly interactive and supportive lab environment.

Essential Duties and Responsibilities

  • Manages one or more independent research projects studying the genetic basis of complex traits and diseases using mice. 

  • Manages and oversees multiple strains in the lab’s mouse research colony, including multiple mouse models of genomic changes in humans.

  • Coordinates with and trains lab members on specialized research techniques involving mouse prenatal and postnatal development.

  • Reviews research activities to determine where new information, methods, or collaborations could positively impact projects and improve efficiency of processes.

  • Routinely develops innovative techniques and systems needed to meet the lab’s research goals.

  • Writes and edits research publications, manuscripts, and other scientific papers describing original research.

  • Presents own research updates with other team members on a weekly basis.

  • Trains new lab members in basic techniques of mouse genetics and molecular biology.

  • Serve as point person and schedule coordinator for specialized pieces of scientific equipment such as cryostat microtome and microCT X-ray scanner.

  • Depending on chosen candidate’s research interests and capabilities, there is flexibility to work with cultured cells and stickleback fish as additional research models.

Qualifications

Education
A bachelor's degree in genetics, genomics, molecular biology, evolutionary biology, or a closely related discipline is required. An advanced degree (master's, PhD, etc.) is preferred.

Experience

Hands-on experience with mouse colony work and management is required.

Hands-on experience with genetics, genomics, and molecular biology techniques is required.

Experience with cloning and building constructs is required.

Previous experience with genomic data analysis would be a plus.

Knowledge, Skills, and Abilities

Passion for both collaborative research and independent project work.

Ability to read literature, think creatively, and plan effective experiments.

Strong mentoring, teaching, and interpersonal skills with lab members at all career levels.

Strong verbal and written communication skills.

Strong attention to detail and high degree of accuracy in research and writing.

Ability to troubleshoot and problem solve while working on interesting research problems at the frontiers of current knowledge.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.


HHMI is an Equal Opportunity Employer

Primary Work Address: Beckman Center, Stanford, CA, 94305-5323


Current HHMI Employees, click here to apply via your Workday account.

We are currently looking for a highly talented, resourceful Research Specialist to join the laboratory of Dr. David Kingsley at Stanford University. The Kingsley lab uses a combination of genetic and genomic approaches to identify the detailed molecular mechanisms that control evolutionary change in vertebrates, with a focus on five fundamental questions:
1. Are key evolutionary traits controlled by countless genetic differences of small effect, or by a few genetic changes with large effects?
2. What specific genes have changed to produce interesting evolutionary differences seen in nature?
3. What kinds of mutations have occurred in these genes (e.g., dominant or recessive, coding or regulatory, preexisting or de novo)?
4. How predictable is evolution? If you know how evolution has occurred in one population, is it possible to predict the types of genes and mutations that also underlie the same trait in different populations or species?
5. How has evolution produced the unique characteristics, and the common traits and diseases, found in humans?
The lab studies these questions using a variety of genetic and genomic methods in mice, stickleback fish, and human beings. More information about the Kingsley lab can be found here: https://kingsley.stanford.edu/

This is a dynamic position that will contribute broadly to the Kingsley lab’s goals while also managing one’s own independent research projects. The ideal candidate enjoys bench research, has strong interpersonal skills, and has the ability to serve as a trusted resource and mentor for more junior lab team members in a highly interactive and supportive lab environment.

Essential Duties and Responsibilities

  • Manages one or more independent research projects studying the genetic basis of complex traits and diseases using mice. 

  • Manages and oversees multiple strains in the lab’s mouse research colony, including multiple mouse models of genomic changes in humans.

  • Coordinates with and trains lab members on specialized research techniques involving mouse prenatal and postnatal development.

  • Reviews research activities to determine where new information, methods, or collaborations could positively impact projects and improve efficiency of processes.

  • Routinely develops innovative techniques and systems needed to meet the lab’s research goals.

  • Writes and edits research publications, manuscripts, and other scientific papers describing original research.

  • Presents own research updates with other team members on a weekly basis.

  • Trains new lab members in basic techniques of mouse genetics and molecular biology.

  • Serve as point person and schedule coordinator for specialized pieces of scientific equipment such as cryostat microtome and microCT X-ray scanner.

  • Depending on chosen candidate’s research interests and capabilities, there is flexibility to work with cultured cells and stickleback fish as additional research models.

Qualifications

Education
A bachelor's degree in genetics, genomics, molecular biology, evolutionary biology, or a closely related discipline is required. An advanced degree (master's, PhD, etc.) is preferred.

Experience

Hands-on experience with mouse colony work and management is required.

Hands-on experience with genetics, genomics, and molecular biology techniques is required.

Experience with cloning and building constructs is required.

Previous experience with genomic data analysis would be a plus.

Knowledge, Skills, and Abilities

Passion for both collaborative research and independent project work.

Ability to read literature, think creatively, and plan effective experiments.

Strong mentoring, teaching, and interpersonal skills with lab members at all career levels.

Strong verbal and written communication skills.

Strong attention to detail and high degree of accuracy in research and writing.

Ability to troubleshoot and problem solve while working on interesting research problems at the frontiers of current knowledge.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.


HHMI is an Equal Opportunity Employer

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