Research Specialist A/B

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Posted Job Title

Research Specialist A/B

Job Profile Title

Research Specialist A

Job Description Summary

The Raabe Laboratory at the Perelman School of Medicine, University of Pennsylvania, is seeking a highly motivated Research Specialist A/B to join our research program focused on liver disease, fibrosis, and regenerative medicine.

Job Description

The work  includes a variety of cutting-edge molecular and cell biologic techniques to investigate the role of senescence and other fibrosis related pathways  in human liver derived organoids and  primary human cells in the context of liver disease. Relevant diseases include viral infections and age related fibrotic liver diseases.  This work will involve genome editing using CRISPR/Cas9 and siRNA techniques both in organoids /cells and in related mouse models - mostly performed by using lipid nanoparticles. The work involves basic cell culture experimentation (including cell transfection/transduction, stimulation and time course collection), molecular biologic assays (SDS-PAGE, Immunoblotting), and fluorescence microcopy as well as  basic data quantification and analysis. The position will also involve assisting with maintaining mouse models,   lab organization through ordering of equipment/reagents, maintaining stocks, reagents, chemicals, records, and lab instruments, and attending planning and review meetings. Other duties as assigned.

Research Specialist A: Will work with Dr. Tobias Raabe and team members under general supervision to perform a variety of tasks including; genetic, molecular, and cell biologic techniques to characterize the role of senescence in human liver derived organoids including CRISPR and siRNA - based genome editing. Assist with related mouse experiments.  Help with lab organization by ordering reagents and materials, maintaining lab stocks, keeping records, and maintaining lab instruments. Other duties as assigned.

The Research Specialist B position will undertake the duties outlined for the Research Specialist A position, with the additional expectation that the candidate will work independently to develop novel methods and techniques, in addition to undertaking established methods and techniques. This position would also have the added expectation of performing some methods/techniques/data analysis independently, and have a background including more experience, specifically with skills necessary to do data analysis and compilation using appropriate software.

QUALIFICATIONS:

Research Specialist A:

• Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.
• Prior experience with mammalian cell culture, molecular/cell biology is strongly preferred.
• Ability to work independently and apply critical thinking and sound judgment
• Excellent organizational and time management skills
• Ability to work with a multi-disciplinary team

Research Specialist B:

• A Bachelor's Degree is required and 1 to 2 years of experience or equivalent combination of education and experience.
• Prior experience with mammalian cell culture and molecular/cell biology is required. Prior experience  with mouse related work preferred.  
• Ability to work independently and apply critical thinking and sound judgment
• Excellent organizational and time management skills
• Ability to work with a multi-disciplinary team

Job Location - City, State

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$45,278.00 - $67,409.00 Annual Rate

Salary offers are made based on the candidate’s qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job’s level. Internal organization and peer data at Penn are also considered.

Equal Opportunity Statement 

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

Special Requirements 
Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

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• Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.

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To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay