Research Scientist, Cancer Biology

Current UC employees must apply internally via SuccessFactors > http://bit.ly/UCEMPL

Founded in 1819, the University of Cincinnati embarks upon its third century – building on the past and defining the future by leading urban, public universities into a new era of innovation and impact through its strategic direction, Next Lives Here . Underscoring the power of creativity, ingenuity, invention and inclusion, what’s Next will accelerate our unrivaled momentum, evidenced by eight straight years of record enrollment and rankings that include placement among America’s top 100 public universities by U.S. News & World Report. Home to a diverse student body of nearly 47,000 and more than 4,200 distinguished faculty, the university combines its Research 1 (Very High Research Activity) Carnegie Classification with a physical setting that The New York Times recently acclaimed as “the most ambitious campus design program in the country.

As one of the oldest medical schools in the country, the University of Cincinnati College of Medicine (COM) has a reputation for training best-in-class health care professionals and developing cutting-edge procedures and research that improves the health and clinical care of patients. In partnership with the UC Health academic healthcare system and Cincinnati Children’s Hospital Medical Center, College of Medicine’s faculty are transforming the world of medicine every day.

The Department of Cancer Biology at the University of Cincinnati has an opening for a Research Scientist supported by NCI R01 to study transcriptional and epigenetic gene regulation in breast cancer metastasis and therapeutic resistance. The Zhang laboratory currently focuses on elucidating the role and molecular mechanisms of gene- and tissue-specific transcriptional cofactors and small RNAs (e.g. miRNA, enhancer RNA) in above processes in breast cancer cells and tumor microenvironment [ACS Nano (2017) 11(1):335, Cancer Research (2018) 78(2):422, Estrogen Receptor and Breast Cancer – Celebrating the 60th Anniversary of the Discovery of ER (1st ed, 2019, Springer Nature), Dev Cell (2021)56(3):341, Cell Reports (2021) 34(10):108822]. We are using a combination of biochemical, molecular, genomic, and mouse genetic (conditional knockout, mutant knockin, and overexpression) approaches. We are also currently developing RNA-based nano-therapeutics to target these cofactors and small RNAs to overcome the therapeutic resistance of human breast cancer.
 
 

Primary Duties Include:

• Independently design and conduct the research required by the faculty supervisor to a high standard and in accordance with all institutional and federal regulations.
• Support the development of proposals for research-related funding and grants. 
• Write manuscript and engage in the dissemination of the results of the research.
• Partake in appropriate training and professional development opportunities.

• Modify and adapt experimental protocols, techniques and procedures to specific project requirements. 
• Design, coordinate and conduct experimental procedures. 
• Prepare research results and written summaries of results in manuscript form for publications and in graphics form for presentation at research meetings and for grant proposals. 
• Maintain and ensure compliance with regulatory protocols and records.
• May submit research proposals as principal investigator for intramural/extramural funding.
• May provide direct and/or indirect supervision to exempt and non-exempt staff (i.e., hiring/firing, performance evaluations, disciplinary action, approve time off, etc.). 
• Perform related duties based on departmental need. This job description can be changed at any time.

• Ph.D., M.D., or M.D./Ph.D., required.  
• Excellent oral and written communication skills

Prior experience with animal studies, small RNAs, or tumor microenvironment is a plus.
 

• Sitting - Continuously
• Repetitive hand motion (such as typing) - Often
• Hearing, listening - Often
• Talking - Often
• Standing - Often
• Walking - Often
• Bending - Seldom
• Stooping - Seldom
• Climbing stairs/ladders - Seldom
• Kneeling, squatting - Seldom
• Crouching - Seldom
• Crawling - Seldom
• Reaching overhead - Seldom
• Lifting - up to 20 pounds - Seldom
• Lifting - up to 50 pounds - Seldom
• Lifting - over 50 pounds - Seldom

Compensation and Benefits

UC offers a wide array of complementary and affordable benefit options, to meet the financial, educational, health, and wellness needs of you and your family. Eligibility varies by position and FTE.

• Competitive salary range dependant on the candidate's experience.
• Comprehensive insurance plans including medical, dental, vision, and prescription coverage.
• Flexible spending accounts and an award-winning employee wellness program, plus an employee assistance program.
• Financial security via our life and long-term disability insurance, accident and illness insurance, and retirement savings plans.
• Generous paid time off work options including vacation, sick leave, annual holidays, and winter season days in addition to paid parental leave.
• Tuition remission is available for employees and their eligible dependents.
• Enjoy discounts for on and off-campus activities and services.

The University of Cincinnati, as a multi-national and culturally diverse university, is committed to providing an inclusive, equitable and diverse place of learning and employment. As part of a complete job application you will be asked to include a Contribution to Diversity and Inclusion statement.

As a UC employee, and an employee of an Ohio public institution, if hired you will not contribute to the federal Social Security system, other than contributions to Medicare. Instead, UC employees have the option to contribute to a state retirement plan (OPERS, STRS) or an alternative retirement plan (ARP).

The University of Cincinnati is an Affirmative Action / Equal Opportunity Employer / Minority / Female / Disability / Veteran.

REQ: 73047 

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