Research Professional

Department
 

BSD PAT - Schreiber Lab

About the Department
 

The laboratory focuses on the separate as well as combined therapeutic effects of CD4 and CD8 T cells recognizing mutation-encoded cancer-specific antigens on murine or human cancers. The Schreiber laboratory has contributed to a number of important discoveries in the field of cancer immunotherapy, including the identification of the genetic nature of unique tumor-specific antigens and that non-synonymous single nucleotide substitutions causing single amino acid replacements are the basis of the unique individually specific immunogenicity of cancers. The Schreiber lab uses mouse models to study T cell-mediated immunotherapy of progressively growing tumors and how tumor-stroma modifies the therapeutic outcome. The lab uses a combination of sophisticated in vivo and in vitro methodologies (including imaging) ranging from the molecular, cell culture, tissue to the whole-body level.

Job Summary
 

The job facilitates and promotes a research project or contributes to the scientific direction of a research resource. Receives a moderate level of guidance and direction. Research Professional will study/develop adoptive T cell therapies in mouse models and humans using syngeneic/autologous mutation specific TCRs engineered to be expressed in peripheral blood T cells. The incumbent will work in close collaboration with our team of leading scientists at the University of Chicago and abroad.

Responsibilities

• Directs a comprehensive program leading to the development of autologous T cell-receptor (TCR) therapy targeting cancer-specific mutations in mice as well as in patients.

• Not only conducts experiments and assays but also trains and guides members of the laboratory. Collaborates with a bioinformatics group to identify the trunk mutations that are well expressed.

• Selects appropriate tumor-specific targets for therapy.

• Renewal and updating of existent and/or completion of new animal research, biosafety and radiation as well as clinical research protocols.

• Making, ordering, training and receiving of culture media and reagents.

• Preparation of sterile supplies including glassware. Training and supervision of others to take over these tasks. 

• Writes up (detailed design) and executes experiments discussed with the principle investigator (PI). Training and supervision of others to take over these tasks. 

• Maintaining a liquid nitrogen cell bank. Training and supervision of others to take over these tasks. 

• Guides, motivates and encourages incoming graduate and undergraduate students, postdoctoral fellows, residents and visiting researchers, and to interact productively with other faculty inside and outside the University.

• Serves as a resource for collecting data and performing analysis. Contributes to facilitating and promoting a research project by providing scientific or intellectual information.

• Reviews laboratory protocols and training on new techniques. Manage complex data sets for research.

• Leads the contributions to scientific writing and publications, including protocols and grants.

• Trains new laboratory personnel.

• Performs other related work as needed.

Minimum Qualifications
 

Education:

Minimum requirements include a PhD in related field.

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Work Experience:

Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.

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Certifications:

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Preferred Qualifications

Education:

• A doctoral degree in molecular biology, genetics, or immunology.

Experience:

• Experience in 10xGenomics preparation and downstream analyses, NSG analyses, TIL, B and T cell cultures and separation techniques, vector construction and methods for TCR transfer by viral transduction, electroporation and CRISPR-CAS.

​Preferred Competencies

• Excellent knowledge of cellular and molecular immunology, and genetics with strong wet lab skills in these areas.

• Demonstrated independence in experimental design and execution.

• An excellent knowledge of spoken and written English.

• Excellent quantitative skills. 

• Understand the ongoing research projects and related literature, participation in journal clubs and research seminars and training.

• Ability to conduct research independently.

• Ability to work effectively in a collaborative team setting.

• Proficiency in computers, particularly data base search and data entry. Maintain procedure and reagent books.

• Ability to perform the duties of other team members in the laboratory for backup, demonstration, and training.

Working Conditions

• Lab environment.

• Work with animals (small rodents).

• Occasional weekend and evenings hours.

Application Documents

• Resume (required)

• Cover Letter (preferred)

When applying, the document(s) MUST  be uploaded via the My Experience page, in the section titled Application Documents of the application.

Job Family
 

Research

Role Impact
 

Individual Contributor

FLSA Status
 

Exempt

Pay Frequency
 

Monthly

Scheduled Weekly Hours
 

40

Benefits Eligible
 

Yes

Requires Compliance with University Covid-19 Vaccination Requirement
 

Yes

Drug Test Required
 

Yes

Health Screen Required
 

Yes

Motor Vehicle Record Inquiry Required
 

No

Posting Statement
 

Employees must comply with the University’s COVID-19 vaccination requirements. More information about the requirements can be found on the University of Chicago Vaccination GoForward .
The University of Chicago is an Affirmative Action/ Equal Opportunity/Disabled/Veterans Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national or ethnic origin, age, status as an individual with a disability, protected veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.

 

Staff Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.

 

We seek a diverse pool of applicants who wish to join an academic community that places the highest value on rigorous inquiry and encourages a diversity of perspectives, experiences, groups of individuals, and ideas to inform and stimulate intellectual challenge, engagement, and exchange.

 

All offers of employment are contingent upon a background check that includes a review of conviction history.  A conviction does not automatically preclude University employment.  Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.

 

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