Research Lab Specialist Senior

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How to Apply

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Summary

The Kalantry laboratory in the Department of Human Genetics (DHG) seeks a highly-motivated Senior Research Laboratory Specialist.  The laboratory studies elucidating principles of epigenetic inheritance through the study of X-chromosome inactivation.  The goal for this position will be to focus on molecular genetic dissection of the process of X-chromosome inactivation. The selected candidate will be able to lead and drive the project independently under Dr. Kalantry's limited direction.  The selected candidate will train students and research staff, and interact with and mentor graduate students and postdocs.  This individual will also directly supervise any temporary student employees working on this project. 

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Who We Are

The Department of Human Genetics at Michigan Medicine is recognized as the first dedicated human genetics department in the United States.  The DHG is one of nine basic science departments in the Medical School with primary missions of teaching and research devoted to advancing the fields of genetics and genomics to further our understanding of biology and human disease.  The Department is growing as faculty are presently being recruited.  We enjoy social functions as a Department, including a yearly department picnic and a yearly department retreat.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world’s most distinguished academic health systems.  In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

• Excellent medical, dental and vision coverage effective on your very first day
• 2:1 Match on retirement savings

Responsibilities*

• Design and Perform Experiments: Experimentation responsibilities include, but are not limited to:
  
  • Derive and culture a variety of stem cell lines from early mouse embryos, including embryonic stem cell (ESC) lines, epiblast stem cell (EpiSC) lines, extraembryonic endoderm (XEN) cell lines, and trophoblast stem cell (TSC) cell lines.
  • Genetically modify and characterize ESC, EpiSC, XEN, and TSC lines  through a variety of molecular means, including CRISPR/Cas9.
  • Isolate and profile RNA and protein expression in early mouse embryos.
  • Clone DNA sequences into plasmid vectors.
  • Generate cDNA and genomic DNA libraries for high-throughput sequencing.
  • Perform immunofluorescence and RNA fluorescence in situ hybridization (FISH) in cultured cells and mouse embryos.
• Chromatin Profiling: Complete chromatin profiling through chromatin immunoprecipitation (ChIP) sequencing, CUT&Tag, and CUT&RUN techniques.
• Document Experiments, Results, and Conclusions: Accurately document all experiments, results, and conclusions.
• Train and Assist Lab Members: Assist others in the lab with the above experimental and chromatin profiling techniques and approaches.  This position will also train new members of the lab, including research staff, graduate students, and undergraduate students, on laboratory protocols and operations, and experimental procedures. This position will directly supervise undergraduate students and mentor graduate students and post-docs.
• Analyze and Present Data: Complete analysis using a variety of molecular, biochemical, and biophysical methods, and present data to relevant audiences, such as at lab meetings and seminars.
• Read Literature and Contribute to Manuscripts, Grants, and Presentations: Read, interpret, and analyze relevant literature. Under the direction of the faculty lab director, prepare materials for manuscripts, grants, and presentations, such as charts, graphs, or written portions of grants.

Required Qualifications*

• Ph.D. in genetics.  
• At least 6 yrs of experience in molecular genetics post-graduation.
• Expertise in molecular biology, specifically with experimental design and execution.
• Experience with stem cell derivation and culture, CRISPR/Cas9-based genomic mutagenesis, chromatin profiling, generating cDNA and genomic DNA libraries for high-throughput sequencing.  
• Experience with mouse embryology.
• Experience with writing scientific manuscripts.
• Experience with data analysis and presenting talks and seminars.
• Experience training others and cultivating positive relationships within the lab and the department.
• Ability to comply with all university, medical school, departmental, and lab rules and regulations.

Desired Qualifications*

• More 6 yrs of experience in molecular genetics post-graduation.

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.