Research Associate - Preclinical Team

Details

Posted: 10-Apr-24

Type: Full-time

Salary: Open

Categories:

Other Staff/Administrative
Staff/Administrative

Internal Number: REQ-2565

Who we are:

The Gladstone Institutes is an independent, not-for-profit research institution. Its mission is to improve the health and well-being of all people through medical research and education in neuroscience, cardiovascular biology, immunology, and stem cell biology. Home to notable leaders in science and biomedicine, Gladstone comprises five institutes as well as various centers and programs. All of its approximately 600 members are aligned in their mission to carry out or support science that overcomes disease. Located in an award-winning building at the Mission Bay Campus, Gladstone offers a competitive salary and benefits program. It provides an ideal environment for those seeking to maximize and fully leverage their potential. Consider Gladstone and make a difference in human health.

About the role:

The Gladstone-UCSF Institute of Genomic Immunology is recruiting a Research Associate (RA) to perform in vivo experiments in mouse models of immunotherapies for ongoing multidisciplinary cellular engineering projects. Our institute has pioneered the application of novel genetic engineering technologies such as CRISPR to primary human immune cells. These new technical abilities have furthered our research into the genetic control of T cell biology as well as opened the door to novel cancer immunotherapies based on engineered human immune cells. This individual would be part of a preclinical research team under the direction of Justin Eyquem (UCSF) streamlining the generation, benchmarking, and functional assessment of genetically engineered human T cell therapies for cancer and inflammatory disease.

What you will do:

• The RA will be trained in experimental procedures involving mouse models of cancer and autoimmune disease and participate in rigorous assessments of the in vivo efficacy of T-cell therapies in these models. Tasks require routine handling of mice.

• Perform routine mouse colony management duties (ear punching/ear tagging/tailing for genotyping, weaning, aging and sexing of pups, and euthanasia, et al).

• Identify and implement required care for mice with health issues and mice on special treatment (special diet, fasting, treated water).

• Learn and become proficient with techniques related to cancer models, such as intravenous injections of cancer cell lines and/or immune cells by tail vein injection or retro-orbital injection; administer medication/reagents orally or via IV, IP, IM, or subQ.

• Learn and become proficient with in vivo imaging (bioluminescence) and other tumor assessment techniques.

• Learn and become proficient with tissue collection and processing, e.g. blood, spleen, lymph nodes, engrafted tumors, or other tissues of interest for downstream analysis.

• Maintain mouse database using Google Sheets or mouse colony software.

• Genotyping via PCR followed by electrophoresis or Sanger sequencing.

• Place genotyping orders in TransnetYX and interpret the genotyping results.

• Maintain and ensure a safe laboratory environment and work practices. Follow standard operating procedures (SOP) and IACUC protocols.

• Other related duties as assigned

What you will need:

• BA/BS degree and one or more years of laboratory experience utilizing techniques or methods required by the position; or an equivalent combination of education and experience

• Must be able to work with mouse colonies

• Experience with general laboratory techniques, especially basic vivarium techniques (mouse handling, injection, digestions). Molecular and cellular biology techniques are preferred (including but not limited to DNA and RNA isolation, PCR, gel electrophoresis)

• Excellent attention to detail, organizational and interpersonal communication skills (verbal and written)

• Willingness and ability to learn new methods and skills for changing research priorities

• Ability to work independently and as a member of a research team

• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines

• Ability to comply with policies and procedures

• Some evening and weekend hours are required

What is preferred:

• Prior experience with mammalian cell culture, especially T cell culture

• Prior experience with immunotherapy studies in animal models

If this role is not for you:

Please stay in touch and to see a complete list of our open career opportunities, please visit:

https://gladstone.org/careers

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About Gladstone Institutes
The Gladstone Institutes is an independent, not-for-profit research institution affiliated with the University of California San Francisco (UCSF), transforming the health and well-being of all people through medical research, education, and outreach in the fields focused on heart disease, immunology and virology including HIV/AIDS, and neurological disease. Home to notable leaders in the field of medical science, including 2012 Nobel Prize in Physiology or Medicine recipient Shinya Yamanaka, M.D.,Ph.D. Gladstone is comprised of four institutes in addition to various Centers and programs focusing approximately 500 members of our team on its mission: Science Overcoming Disease. Located in an award-winning building adjacent to UCSF's Mission Bay Campus, Gladstone offers a competitive salary and benefits program within a robust environment for those seeking to maximize their potential. Please consider Gladstone and make a difference in human health.
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