Research Associate I- Guarnerio Lab

Requisition # HRC0729401

Cedars-Sinai Medical Center ranks among the nation’s top ten non-university hospitals receiving federal funding for research and currently has more than 1,500 active research projects. Cedars-Sinai Cancer Center supports basic and clinical research in many cancer-related areas and researchers are seeking more effective ways to diagnose, treat and prevent many forms of cancer.

Cedars-Sinai is situated in the heart of Los Angeles at the border with Beverly Hills, in a very dynamic area of the city, and in the proximity of the University of California Los Angeles (UCLA). Competitive salary and excellent benefits are also provided.

Guarnerio Lab

Our lab's goal is to understand the interactions between highly aggressive cancers and the non-malignant cells of the microenvironment in order to identify molecular vulnerabilities and develop novel therapies, especially in sarcoma and leukemia. We work in a highly collaborative environment incorporating functional genomics, proteomics and biochemistry approaches that include single-cell and spatial single-cell transcriptomics, mass-cytometry, Hyperion imaging, and state of art mass spectrometry technologies.

We are seeking highly motivated individuals interested in being involved in research projects in one of the following areas:

Sarcoma Microenvironment

Soft-tissue sarcomas comprise a heterogeneous group of aggressive tumors that originate from cells belonging to the mesenchymal lineages. Compared to epithelial carcinomas, sarcomas have been less studied, and lack effective therapeutic alternatives to radiation and chemotherapy. With the aim of identifying new and more effective therapies for these tumors, the lab is employing syngeneic mouse models (Guarnerio et. al., Cancer Discovery 2015 ) to study immune and non-immune cells of the tumor microenvironment through single-cell transcriptomics and functional genomics.

Cancer-associated circRNAs in the microenvironment

We have previously discovered tumor-associated circular RNAs (circRNAs) that act as oncogenes in the process of tumorigenesis (Guarnerio et. al. Cell 2016 ). More recently, we have observed that circRNAs can impact the tumor cells’ “secretome” and ultimately the composition of the tumor microenvironment (Guarnerio et. al., Cell Res 2019 ). Using novel biochemistry techniques refined in our lab, we are studying the unique mechanisms by which tumor-associated circRNAs define the immune and non-immune composition of the tumor mass.

For more information please visit:https://www.cedars-sinai.edu/Research/Research-Labs/Guarnerio-Lab/

The ideal candidate should have:

• Technical proficiency in cell culture and hands on mouse work (s.c, i.v, i.p. injections).
• Some experience in flow and/or mass cytometry.
• Individuals with training in cancer biology and functional genomics techniques (i.e. shRNA and CRISPR/Cas9 tools) are particularly encouraged to apply.
• Training in statistics or programming is a big plus but not required.

• Excellent oral and written communication skills.
• Ability to perform and prioritize multiple simultaneous tasks.
• Candidate should be industrious, highly collaborative, and enthused by a vibrant team environment.

Responsibilities:

• Help to organize and manage experiments in a dynamic environment

• Execute, and critically interpret experiments and present data in a cogent and compelling manner
• Present data at lab meetings
• Under the direction of the PIs, assist in drafting study protocols

Education: BS or MS Degree

Experience:

• Technical proficiency in cell culture and hands on mouse work (s.c, i.v, i.p. injections).
• Some experience in flow and/or mass cytometry.
• Individuals with training in cancer biology and functional genomics techniques (i.e. shRNA and CRISPR/Cas9 tools) are particularly encouraged to apply.
• Training in statistics or programming is a big plus but not required.
• Excellent oral and written communication skills.
• Ability to perform and prioritize multiple simultaneous tasks.
• Candidate should be industrious, highly collaborative, and enthused by a vibrant team environment.

Physical Demands:

Lifting, Standing, Sitting, Walking, Typing, Bending

• Working Title: Research Associate I- Guarnerio Lab
• Department: Radiation Oncology Academics
• Business Entity: Academic / Research
• City: Los Angeles
• Job Category: Academic/Research
• Job Specialty: Research Studies/Clinical Trials
• Position Type: Full-time
• Shift Length: 8 hour shift
• Shift Type: Day

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at [email protected] and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu) and COVID-19. For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through April each year) as a condition of employment, and annually thereafter as a condition of continued employment, subject to medical exemption or religious accommodation. For the same reason, you may also be required to receive other vaccines such as COVID-19 as a condition of employment. Cedars-Sinai reserves the right to make modifications to its required list of vaccines as required by law and/or policy.

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