Principal Scientist, Cancer Cell Programs (Post-CAN Research)

Pfizer's Oncology Research Unit (ORU) unit in La Jolla, California, is seeking a Principal Scientist (PhD) to join the Post-CAN Research group focused on translating basic discoveries in the field of cancer cell biology into novel therapeutics.

The Principal Scientist will work within a collaborative team of motivated and scientifically rigorous scientists to conduct preclinical research and advance our clinical and pre-clinical drug programs in the field of cancer cell biology. Our ideal candidate will have a strong background employing state-of-the art approaches to gain a broader understanding of transcriptional regulation in cancer biology. Experience in DNA damage repair (DDR)/genome integrity is a plus. The candidate will translate basic research findings into therapeutic strategies, utilizing genetic and pharmacological approaches to understand target mechanism of action, generate patient stratification strategies and identify rational drug combinations. The successful candidate will demonstrate a proven track record of scientific productivity as evidenced by first author publications in scientific journals. Experience in the integration of molecular profiling data including epigenomic (ATAC-seq, ChIP-seq), transcriptomic, proteomic, and genomic datasets will be preferred.

ROLE RESPONSIBILITIES

• Utilize expertise in epigenetic biology to develop innovative strategies for understanding the role of transcriptional mechanisms in cancer progression, drug resistance and immune modulation
• Design, execute and analyze/interpret experiments to advance mechanism of action studies, develop patient responder hypotheses, elucidate mechanisms of resistance and identify rational drug combinations that can be translated to the clinic
• Work collaboratively with computational biology group to integrate complex data sets including epigenomic and other 'omic' data in pre-clinical settings for target validation and increased understanding of target biology
• Interface with discovery biology, discovery technologies, computational biology, ADC biology and clinical groups to design, develop, and interpret datasets to support program progression
• Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program
• Present research results and methodologies at weekly meetings with immediate supervisor and/or project leader, project team meetings and other research forums
• Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.

Basic Qualifications

• PhD or MD/PhD in Molecular or Cellular Biology, Genetics, Pharmacology (or a comparable biological science) with 5+ years of relevant postdoctoral experience in an academic or pharmaceutical/biotech environment. Prior industry experience is preferred.
• Expertise in chromatin biology, epigenetics and mechanism of transcriptional regulation as evidenced by publication in peer-reviewed journals.
• Preference for candidates with a strong track record in cancer drug discovery/translational research and the targeting of epigenetic pathways by small-molecule inhibitors.
• Expertise in techniques used for epigenetic/ transcriptional profiling including ChIP-seq, ATAC-seq, nascent and bulk RNA-seq
• Able to work in a team environment, good communication skills and excellent leaderships skills

• Proficiency in integration of molecular profiling data including epigenomic (ATAC-seq, ChIP-seq), transcriptomic, proteomic, and genomic datasets
• Extensive knowledge and understanding of other areas of cancer cell biology including but not limited to DNA damage and repair, immuno-oncology, oncogenic signaling, ADC biology and/or apoptosis
• Experience supporting IND study reports or contributing to relevant sections of IND study reports
• Experience in use of CRISPR-based techniques for gene knockout, gene editing and as well as working knowledge of pooled CRISPR -based screening approaches
• Managerial experience, preferably in industry research and development setting

Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development