Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.
A postdoctoral position to study the signaling mechanisms regulating epithelial stem cell fate decisions is available in the lab of Dr. Aron Jaffe (https://www.novartis.com/our-science/postdoc-program/research-themes/regenerative-medicine/aron-jaffe-phd) in the Respiratory Diseases Department. The generation, maintenance, and repair of epithelial tissues require the coordinated regulation of multiple cellular processes, such as cell polarity, cell-cell and cell-matrix interactions, and differentiation. We utilize in vivo and two- and three-dimensional culture models of epithelial morphogenesis, and employ a variety of screening and profiling methods to identify novel pathways regulating key cellular processes involved in morphogenesis. We are particularly interested in the mechanisms regulating epithelial progenitor cell fate decisions, because an imbalance in the differentiated cell types is observed in several pulmonary epithelial diseases, such as asthma and chronic obstructive pulmonary disease (COPD). We want to understand how epithelial progenitors choose to differentiate down a particular lineage, and how that decision is de-regulated in disease.
The work in the Jaffe lab is currently directed towards addressing three key goals:
1. Identification and characterization of the signaling pathways regulating airway basal cell fate decisions in normal and disease settings.
2. Understanding the mechanisms regulating the production and function of rare cell types in the airway.
3. Identifying the mechanisms regulating airway squamous metaplasia.
We seek highly motivated postdoctoral fellows to join our research group. The successful candidate will use cDNA and CRISPR screens, proteomics, single-cell RNA-seq, and chemical biology approaches to dissect the regulation of epithelial morphogenesis, and will capitalize on access to multidisciplinary expertise and cross-departmental state-of-the-art resources at Novartis. Fellows will have ample opportunity and support to publish their findings in peer-reviewed, high-impact journals. This is a unique opportunity for an independent, self-motivated candidate to enhance his/her academic training and professional horizons.
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