Postdoctoral Researcher - Cellular Signaling

Updated: about 18 hours ago
Location: Indiana, PENNSYLVANIA
Deadline:

Posting Details

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Title Postdoctoral Researcher - Cellular Signaling
Specific Title Postdoctoral Appointee
Appointment Type Postdoctoral Fellow
Department IUSM - Pharmacology & Toxicology
Campus IU School of Medicine Indianapolis
Position Summary

We are accepting applications for a postdoctoral fellow interested in the study of cellular signaling and the regulation of gene expression in the protozoan parasite Toxoplasma gondii. Toxoplasma is an opportunistic pathogen that causes severe disease in congenitally infected infants and immune compromised patients. Toxoplasma is a significant clinical challenge because the parasite converts into a latent tissue cyst form that evades immunity and current drugs. The tissue cysts are central to pathogenesis, transmission, and behavioral changes in the host.

Our laboratory seeks to solve this clinical problem by obtaining a better understanding of the mechanisms driving tissue cyst formation. We use state-of-the-art multi-disciplinary approaches to interrogate how the parasite alters translation and reprograms its genome to convert to the latent stage of infection.

The successful applicant will contribute to exciting projects examining the myriad ways gene expression is regulated in the context of cyst formation. This includes study of multiple mechanisms including transcription, epigenetics, epitranscriptomics, and translational control. Our long-term goal is to identify novel points of therapeutic intervention that will thwart the development and maintenance of Toxoplasma tissue cysts.

This is a NIH position in the laboratory of Bill Sullivan
https://wjsulliv.wixsite.com/sullivanlab

Our laboratory is a part of the “BIP” (Biology of Intracellular Pathogens) group at the Indiana University School of Medicine (IUSM): http://wjsulliv.wix.com/bipatiu.

At the IU School of Medicine, we offer focused, systematic and sustained programs that are aligned with three foundational pillars of diversity and inclusion: representational diversity, inclusive working and learning environment, and cultural competence. Therefore, we are looking for applicants who can help ensure all our mission areas are inclusive and equitable.

Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named “Best Airport in North America” by Airports Council International for many years. For additional information on life in Indy: https://www.nomeancity.com.

Basic Qualifications

The position requires a Ph.D., expertise in cell/molecular biology or biochemistry, and excellent communication skills

Department Contact for Questions

wjsulliv@iu.edu

Additional Qualifications
Special Instructions

A current CV and contact information for three references are required. Please email these to Dr. Sullivan at wjsulliv@iu.edu

Priority Application Review Deadline
Expected Start Date
OAA # IUSM009042016

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