Position Information
Job Posting Number | S00951 |
---|---|
Position Title | Postdoctoral Research Associate |
Department | Chemistry Department-1093 |
Job Category | Staff Posting |
Position Type | Grant Funded Full-Time |
Pay Type | Salaried |
Salary Range | $50,800 – $59,500 – $65,292 |
Compensation Practices | Experience is taken into consideration in the determination of salary offers. For more information visit https://www.wesleyan.edu/hr/handbook/compensation-practices/index.html |
Position Details | lThe lab of Prof. Colin Smith in the Chemistry Department at Wesleyan University seeks a postdoctoral researcher to work on next-generation computational methods for NMR-based structure determination. The position involves developing, benchmarking, and applying computer code that implements NOE restraints based on our recently developed Kinetic Ensemble approach. We are particularly interested in studying the sensitivity of NOE data to angular protein motion and taking advantage of that to create significantly more accurate structural ensembles. We plan to incorporate algorithms from the FitNMR software package, also developed in the Smith Lab, to extract overlapped peak volumes from raw spectral data, creating a fully quantitative structure determination pipeline. The ultimate goal is to transform how NMR structures are refined and enable elucidation of protein dynamics for all atoms in the protein. Responsibilities include:
Smith Lab web site: http://smithlab.wesleyan.edu Kinetic Ensemble paper: https://doi.org/10.1007/s10858-019-00288-8 FitNMR paper: https://doi.org/10.1016/j.jmr.2020.106773 All computer code will be released using a permissive open-source license, enabling integration in most modern NMR structure determination software packages. This is a grant funded position. Continuation is dependent upon continued funding. |
Minimum Qualifications | PhD in biophysics, chemistry, bioinformatics, computer science or a related field. Experience in scientific software development using a compiled language like C++. Familiarity with object oriented programming. Ability to analyze large-scale datasets. Understanding of protein biophysics and the driving forces behind inter and intramolecular interactions. |
Preferred Qualifications | A minimum of 1yr of experience as a PostDoc. Experience with NMR structure determination. Proficiency running molecular dynamics simulations. Familiarity with the R programing language. Experience programming with a large codebase like Gromacs or Rosetta. Excellent scientific writing and communication skills. |
Management Competencies | Inform others, Innovation management, Manage and measure work, Project management |
Competencies | Creativity and innovation, Dealing with ambiguity, Functional/technical skills, Personal accountability, Problem solving, Time management, Written communications, Commitment to sustainability |
Special Instructions to Applicants | |
Additional Information | Any and all offers to external applicants are contingent on the candidate’s completion of a pre-employment background check screening to the satisfaction of Wesleyan University. Wesleyan requires all employees to be vaccinated against Covid 19 unless they meet the criteria for a medical or religious exemption. New employees must be vaccinated prior to their start date. If an employee needs an exemption for medical or religious reasons, they must submit a request to Wesleyan and be approved before their start date. |
Benefits | Wesleyan offers a broad range of employee benefits and development opportunities, including comprehensive group insurance plans, wellness programs and incentives, generous paid time off and retirement plans. We also offer flexible work schedules, employee and dependent tuition programs, as well as access to Wesleyan’s BLS & GLS programs for those who qualify (tuition is waived for up to 2 courses a term; some fees and taxes may apply). Detailed information on the benefits of working at Wesleyan is located at: https://wesleyan.edu/hr/careers/prospective-resources.html . |
Quick Link | https://careers.wesleyan.edu/postings/8181 |
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