Postdoctoral Research Associate - Snider Lab

University of North Carolina, United States

Updated: over 2 years ago
Location: Chapel Hill, NORTH CAROLINA
Job Type: FullTime
Deadline: 20 Nov 2021

Posting Information
Position Title Postdoctoral Research Associate - Snider Lab
Vacancy ID PDS003211
Department Cell Biology and Physiology - 422001
Position Type Postdoctoral Scholar

Salary Range Dependent on Qualifications/Experience
Full-time/Part-time Full Time
If part-time, hours per week
FTE 1.0
Proposed Start Date 12/06/2021
Estimated Duration of Appointment 12 Months
Posting Open Date 09/20/2021
Posting Close Date 11/20/2021
Open Until Filled No
Work Location Chapel Hill, NC
Position Summary
The department was formed in July 2012 through the merger of the Department of Cell & Developmental Biology and the Department of Cell & Molecular Physiology. The new department brings together two strong traditions of excellence in basic science and translational research, and in pre- and post-doctoral training, including undergraduate, graduate and medical education. 
Our lab studies the biology and pathophysiology of the intermediate filament cytoskeleton. Specifically we are interested in therapeutic approaches for rare genetic diseases caused by a primary defect in the intermediate filament cytoskeleton. We are seeking a postdoctoral fellow to study mechanisms of intermediate filament proteostasis and pharmacological approaches for intervention.  The project will involve studying the molecular, cellular and pathophysiological mechanisms of Giant Axonal Neuropathy using patient-derived iPSC-astrocyte and neurons, brain organoids, and rodent models of disease.  
The position will require: working with rodent models of Giant Axonal Neuropathy; isolation of primary astrocytes and neurons; iPSC cell culture and differentiation; pharmacological studies using FDA approved libraries, kinase inhibitors, and novel intermediate filament targeting compounds; developing biochemical assays for intermediate filaments, assaying filament properties using confocal and electron microscopy on fixed cells/tissues and in vitro assembled proteins. 
Educational Requirements
Candidate must possess a PhD, MD or MD/PhD. 
Qualifications and Experience
Candidate should possess background and skills in cell biology, biochemistry, chemical biology, pharmacology and/or animal models of disease. Previous experience with iPSCs, gene editing and drug screening is desirable. 
Equal Opportunity Employer
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.
Special Instructions
For information on UNC Postdoctoral Benefits and Services click here
Quick Link https://unc.peopleadmin.com/postings/199272
Special Physical and Mental Requirements

Department Contact Name and Title Rose Thorp, HR Consultant
Department Contact Telephone or Email 919-966-9396
Postdoctoral Affairs Contact Information

If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at (919)-962-1091 or send an email to [email protected].

Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.

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