Postdoctoral Research Associate - Medical Oncology

Updated: about 1 month ago
Location: Medical Lake, WASHINGTON
Job Type: FullTime

Job Description

Position Summary

Postdoctoral Research Associate Position Open in the Vindigni Lab (Department of Medicine/Division of Oncology).

Area of expertise: DNA replication, DNA repair, cancer biology.

The Vindigni Lab is seeking a postdoctoral researcher to work on the mechanisms of DNA replication stress response to chemotherapeutics. Our group focuses on DNA replication and repair, and the roles of these pathways in cancer initiation, progression and response to chemotherapy and immunotherapy (https://oncology.wustl.edu/people/faculty/Vindigni/Vindigni_Res.html ). We recently identified new pathways by which replication responds to DNA-damaging chemotherapeutics and provided insights on how to target these pathways to increase chemotherapeutic sensitivity (Tirman et al. , Mol. Cell 2021; Quinet et al. , Mol. Cell 2020; Lemacon et al. , Nat. Comm. 2017; Thangavel et al. , J. Cell Biol. 2015; Berti et al. , Nat. Struct. Mol. Biol. 2013).

The postdoctoral researcher will have the opportunity to acquire and develop new skills, including application of state-of-the-art imaging techniques to study perturbations in replication fork dynamics genome-wide at single-molecule resolution. They will also have the opportunity to work closely within a wide network of basic research and clinical collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications, while working in a supportive, highly collaborative and energetic environment.

In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs . The postdoctoral researcher will have opportunities to acquire and develop new skills, work closely with the PI and collaborators.

Primary Duties & Responsibilities

Trains under the supervision of a faculty mentor, including (but not limited to):

  • Manages their own project, which should lead to a first author publication.
  • Develops expertise in state-of-the-art imaging techniques to study perturbations in replication fork dynamics.
  • Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
  • Presents scientific work both inside and outside the University with excellent oral communication skills.
  • Assists with grant preparation and reporting.
  • Prepares and submits papers on research with excellent writing skills.
  • Designs research experiments.
  • Evaluates research findings and reports results.
  • Maintains conscientious discharge of their research responsibilities.
  • Maintains conformity with ethical standards in research.
  • Maintains compliance with good laboratory practice, including the maintenance of adequate research records.
  • Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
  • Maintains collegial conduct towards co-trainees, staff members and members of the research group.
  • Adheres to all applicable University policies, procedures and regulations.  All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Required Qualifications

  • Ph.D. or MD degree.
  • Solid background in cancer biology, molecular biology or biochemistry.
  • Proven record of creative research achievements.
  • Strong interest in DNA replication/repair and genome maintenance.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

To apply, the candidates should email a cover letter describing their current and previous research experience, CV and contact information for three references to: Alessandro Vindigni, Ph.D. avindigni@wustl.edu .


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

Job Description

Position Summary

Postdoctoral Research Associate Position Open in the Vindigni Lab (Department of Medicine/Division of Oncology).

Area of expertise: DNA replication, DNA repair, cancer biology.

The Vindigni Lab is seeking a postdoctoral researcher to work on the mechanisms of DNA replication stress response to chemotherapeutics. Our group focuses on DNA replication and repair, and the roles of these pathways in cancer initiation, progression and response to chemotherapy and immunotherapy (https://oncology.wustl.edu/people/faculty/Vindigni/Vindigni_Res.html ). We recently identified new pathways by which replication responds to DNA-damaging chemotherapeutics and provided insights on how to target these pathways to increase chemotherapeutic sensitivity (Tirman et al. , Mol. Cell 2021; Quinet et al. , Mol. Cell 2020; Lemacon et al. , Nat. Comm. 2017; Thangavel et al. , J. Cell Biol. 2015; Berti et al. , Nat. Struct. Mol. Biol. 2013).

The postdoctoral researcher will have the opportunity to acquire and develop new skills, including application of state-of-the-art imaging techniques to study perturbations in replication fork dynamics genome-wide at single-molecule resolution. They will also have the opportunity to work closely within a wide network of basic research and clinical collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications, while working in a supportive, highly collaborative and energetic environment.

In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs . The postdoctoral researcher will have opportunities to acquire and develop new skills, work closely with the PI and collaborators.

Primary Duties & Responsibilities

Trains under the supervision of a faculty mentor, including (but not limited to):

  • Manages their own project, which should lead to a first author publication.
  • Develops expertise in state-of-the-art imaging techniques to study perturbations in replication fork dynamics.
  • Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
  • Presents scientific work both inside and outside the University with excellent oral communication skills.
  • Assists with grant preparation and reporting.
  • Prepares and submits papers on research with excellent writing skills.
  • Designs research experiments.
  • Evaluates research findings and reports results.
  • Maintains conscientious discharge of their research responsibilities.
  • Maintains conformity with ethical standards in research.
  • Maintains compliance with good laboratory practice, including the maintenance of adequate research records.
  • Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
  • Maintains collegial conduct towards co-trainees, staff members and members of the research group.
  • Adheres to all applicable University policies, procedures and regulations.  All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.

Required Qualifications

  • Ph.D. or MD degree.
  • Solid background in cancer biology, molecular biology or biochemistry.
  • Proven record of creative research achievements.
  • Strong interest in DNA replication/repair and genome maintenance.

Salary Range

Base pay is commensurate with experience.

Applicant Special Instructions

To apply, the candidates should email a cover letter describing their current and previous research experience, CV and contact information for three references to: Alessandro Vindigni, Ph.D. avindigni@wustl.edu .


Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.


Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.


EEO/AA Statement
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.


Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

View or Apply

Similar Positions