Postdoctoral - Pediatric Brain Tumors (Tailor Lab)

Indiana University, United States

Updated: 1 day ago

Location: Indiana, PENNSYLVANIA

Deadline: ;

Posting Details
Position Details

Title	Postdoctoral - Pediatric Brain Tumors (Tailor Lab)
Specific Title
Appointment Type	Postdoctoral Fellow
Department	IUSM - Neurological Surgery
Campus	IU School of Medicine Indianapolis
Position Summary	A full-time Post-Doctoral Research position is available in the Department of Neurological Surgery. The candidate will assist the principal investigator in conducting research on stem cells and pediatric brain tumors, primarily medulloblastoma and ependymomas. Our research is focused on examining the early steps of tumorigenesis from normal neural stem cells to full blown cancer. We will model brain cancer predisposition syndromes such as Gorlin syndrome, neurofibromatosis, MMRD with iPS and neural stem cells. Candidate must be comfortable with stem cell culture techniques and using whole animal models to study tumor formation and progression in order to discern neoplastic mechanisms and possible therapeutic targets. We are seeking a self-directed, self-motivated, curious, creative, well-organized candidate with extensive experience, stem cell and molecular biology, next-generation sequencing techniques, data analysis, and animal handling to join our team. As the nation’s largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an antiracist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and wellbeing for all throughout the state of Indiana. Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named “Best Airport in North America” by Airports Council International for many years. For additional information on life in Indy: https://faculty.medicine.iu.edu/relocation/. Job Summary Primary Duties and Responsibilities: Advanced molecular biology techniques including gene editing (CRISPR), plasmid design and production, bacterial culture, plasmid purification, and related analyses. Molecular biology and biochemical analyses including Western blotting, protein assays, PCR, RT-PCR, DNA and RNA purification and sequencing. Animal (mouse) handling/manipulations: Perform surgeries/implantations (will train), biopsies, bioluminescence imaging, and drug administration. Extensive tissue culture required. Flow cytometry and microscopy; phenotypic analysis and imaging. Keep organized analytical data of performed experiments and expected to report findings at lab meetings. Acts as a liaison/mentor to technicians, students and other laboratory personnel for training. Responsible for the initiation, monitoring, completion, and reporting of complex and intricate laboratory experiments. Organize and implement data review and analysis. Collaborate with other University Faculty and labs for common goals. Expected to keep current on relevant literature to identify suitable direction, new techniques, procedures and methods. Expected to submit research to national, professional meetings for possible presentations. Expected to publish in peer reviewed journals.
Basic Qualifications	EDUCATION Required Doctorate degree (PhD) in science or related field SKILLS Required Experience with broad range of molecular biology and biochemistry techniques Extensive tissue culture experience Maintains a high degree of professionalism Demonstrated time management and priority setting skills Experience in animal husbandry and related studies (e.g. mouse IP/IV drug administration and tissue dissection) Preferred Neural stem cell culture/ iPS generation/other stem cell research Some bioinformatics experience
Department Contact for Questions	[email protected]
Additional Qualifications
Special Instructions
Priority Application Review Deadline
Expected Start Date
OAA #	IUSM-01671-2023