Postdoctoral Position in Cancer Biology and Genetics (Wilson Lab)
The Wilson laboratory in the Section of Medical Oncology and the Yale Cancer Center is seeking highly-motivated candidates for a postdoctoral position. Interests in the laboratory focus on identifying and characterizing genetic vulnerabilities in cancer and molecular mechanisms of drug resistance with an emphasis on lung cancer therapeutics (https://medicine.yale.edu/bbs/people/frederick_wilson-1.profile). The lab leverages genome-scale CRISPR-based functional genomic screening platforms to identify genetic cancer vulnerabilities and to dissect resistance mechanisms in relevant cancer cell models. The lab also applies DNA- and RNA-based next-generation sequencing technologies to identify candidate driver gene alterations and other potentially actionable genomic features from patient tumor specimens. Mechanistic studies are then leveraged in cell model systems to assess the functional impact of identified genetic alterations. A major priority is to translate laboratory findings into therapeutic strategies for patients with advanced lung and other cancers.
A major emphasis in the laboratory is to provide scientific mentorship through regular meetings with the principal investigator and opportunities for professional development in a supportive and collaborative environment. The postdoc will meet at least weekly with the principal investigator to discuss research progress as well as professional goals and career planning. An important goal is for the postdoc to generate a body of scientific work leading to a first-author peer-reviewed publication.
Applicants should be highly motivated with experience in molecular biology, genetics / genomics, and cancer biology. Of particular interest are candidates with research experience in DNA damage repair (immunostaining for biomarkers of DNA damage, R-loop biology, DNA damage signaling, etc). The candidate must have a recent PhD or MD/PhD degree in a relevant field with a proven track record of scientific productivity including at least one first author publication in a peer-reviewed journal. Excellent written and oral communication skills are expected. The candidate will be expected to work independently in the design and execution of experiments with guidance from the principal investigator. As projects in the laboratory are often highly collaborative, the candidate should be able to work effectively and enthusiastically in a team environment.
Candidates should send a Curriculum Vitae, a statement of research interests and career goals, and names / contact information for three references to: [email protected]. Anticipated start date will be Summer 2024.
Yale University is an Affirmative Action / Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.