Postdoctoral Fellow

Position Description:

One or more full time postdoctoral positions are available immediately for highly motivated postdoctoral scholars interested in vascular or neural mechanisms in blood pressure control related to hypertension in the laboratory of Dr. Curt D. Sigmund in the Department of Physiology at the Medical College of Wisconsin. A qualified candidate for this position is expected to have a strong publication record and excellent references from PhD or postdoctoral research. A notable feature of this postdoctoral fellowship will be experience in combining state-of-the-art genetic and molecular methods (including CRISPR-Cas9 genome editing) with sophisticated physiologic techniques to address fundamental mechanisms of vascular and neural function in genetically modified mouse models in hypertension. Proficiency in physiology or pharmacology and experience with genetics and molecular biology is highly desired.  Potential project includes: 1) examining genomic interactions regulating PPARγ target gene expression in vascular smooth muscle and endothelium, 2) physiological, and proteomic analysis of Cullin-3 adaptors and substrates in vascular smooth muscle and endothelium, and 3) relative role of angiotensin II receptor G protein and β-arrestin signaling related to fluid homeostasis, metabolic function and blood pressure. The successful applicants can be expected to use sophisticated tools in physiological genomics utilizing cell and primary culture, and organ and whole mouse physiology. They will work in a multidisciplinary team with a diversity of interests, ideas, and experiences. 

Full time postdoctoral positions available immediately for highly motivated postdoctoral scholars interested in vascular or neural mechanisms in blood pressure control related to hypertension in the laboratory of Dr. Curt D. Sigmund in the Department of Physiology at the Medical College of Wisconsin. A qualified candidate for this position is expected to have a strong publication record and excellent references from PhD or postdoctoral research. A notable feature of this postdoctoral fellowship will be experience in combining state-of-the-art genetic and molecular methods (including CRISPR-Cas9 genome editing) with sophisticated physiologic techniques to address fundamental mechanisms of vascular and neural function in genetically modified mouse models in hypertension. Proficiency in physiology or pharmacology and experience with genetics and molecular biology is highly desired. Potential project includes: 1) examining genomic interactions regulating PPARγ target gene expression in vascular smooth muscle and endothelium, 2) physiological, and proteomic analysis of Cullin-3 adaptors and substrates in vascular smooth muscle and endothelium, and 3) relative role of angiotensin II receptor G protein and β-arrestin signaling related to fluid homeostasis, metabolic function and blood pressure. The successful applicants can be expected to use sophisticated tools in physiological genomics utilizing cell and primary culture, and organ and whole mouse physiology. They will work in a multidisciplinary team with a diversity of interests, ideas, and experiences.

To post your application, please click here to apply or at Medical College of Wisconsin Careers: Requisition #28135.

You will need to upload a single PDF attachment containing 1) a cover letter indicating your research interests, 2) CV including list of all publications, and 3) list of 3 or more references who can be immediately contacted without further permission. 

Characteristics of a postdoctoral appointment:

It is expected that postdocs at MCW, with the assistance of their supervisor, will:

• Transition to career independence through the development of professional skills that enable the postdoc to actively pursue a career of his/her own choosing.
• Be supervised by at least one senior scholar who actively promotes the postdoc's professional development.
• Establish an individual development plan (IDP) that incorporates equally the postdoc's career and training goals and the mentor's research goals.
• Pursue basic, clinical, or translational projects so long as effort is focused primarily on research.
• Publish results of the postdoc's research and scholarship during their appointment.
• The postdoctoral appointment is temporary by nature, the aggregate amount of time spent as a postdoc is recommended to not exceed five years (not including family medical leave or maternity/paternity leave).
• As postdocs are important members of the host institution's community, appropriate levels of compensation, health care, and other benefits commensurate with their essential status should be afforded, independent of the postdoc's source of funding.

Primary Functions

• Plan, design and execute complex research studies, procedures and protocols.
• Participate in discovery projects.
• Coordinate research study activities; lead and manage projects.
• Oversee organization, synthesis and analysis of data and findings.
• Prepare scientific reports, outcome findings and scientific manuscripts.
• Participate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data, develop methodologies, and design and evaluate lab procedures.
• Maintain supplies, may require negotiation with vendors, and track purchase orders.
• May oversee the work of laboratory personnel including training and development as well as daily work direction, delegation and establishing priorities.

Preferred Schedule:
Monday-Friday; 8:00 am - 5:00 pm

Position Requirements:

Knowledge – Skills – Abilities

Required knowledge: biology, chemistry, mathematics, statistics, documentation, records management, data utilization, complex problem solving, critical thinking, resource management, and writing skills

Specifications

Minimum Required Education: PhD in a scientific field or MD

Minimum Required Experience: None,

Preferred Experience: Experience in physiology or pharmacology and with genetics and molecular biology

MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination
The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.

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