Postdoctoral Fellow - Immune-oncology, Vaccinology and Immunology

JOIN US MARCH 5th!  You’re invited to a live virtual presentation featuring Ajay Goel, Ph.D., AGAF hosted by City of Hope to share insights on his research and provide valuable information to candidates for his programs during this 20-minute live presentation!  Stay for the Q & A session immediately following.  We begin at2 pm and you must register to join:  http://tinyurl.com/2p7yj9vx   Bring your resume’, your questions and a friend!  *All are welcome.

More about Dr Goel here: Ajay Goel, Ph.D., AGAF, Chair, Department of Molecular Diagnostics and Experimental Therapeutics | Beckman Research Institute of City of Hope  

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Postdoctoral Fellowship opportunity is immediately available for a highly motivated individual in the laboratory of Dr. Larry Kwak.  For more information on Dr. Kwak’s research please visit here .

As a successful candidate, you will:

·         Study pre-clinical study for a personalized mRNA cancer vaccine against lymphoma.

·         Use single-cell RNA analysis, you will study cell-intrinsic characteristics of BAFF-R CAR-T correlated with responses that can be used as markers of clinical outcomes.

·         Skills that are used in the lab include: working with mice, mammalian cell culture, primary human cell (BM and PBMC) culture and handling, multi-color FLOW cytometry, ELISA, and cell-sorting, co-culture functional assays.

·         Be familiar with novel single-cell RNA sequencing technologies and analysis pipelines.

·         Highly motivated and self-directed applicants interested in translational research in cancer immunotherapy are strongly encouraged to apply. However, applicants with related training and experience will be given priority.

·         Ph.D. degree with research experience; a track record of publications in peer-reviewed scientific journals.

·         Strong background in immune-oncology, vaccinology and/or immunology.

·         Expertise in multi-parameter FLOW cytometry.

·         Expertise in cell-based assays (e.g. co-culture functional assays, multi-color flow cytometry, ELISA, cell sorting, etc.)

·         Experience executing primary immune cell assays and mechanism of action studies (T cell isolation, expansion, cytokine secretion assays, T cell differentiation, T cell killing assay etc).

Additional Information:

For more scientific background, please refer to our publications:

o   Science 2002 Nov 1; 298(5595):1025-9:       https://doi.org/10.1126/science.1075565

o   Nature Medicine 2005 Sep; 11(9): 986-91:   https://doi.org/10.1038/nm1290

o   BMC Cancer 2018 Feb 13;18(1):                   https://doi.org/10.1186/s12885-018-4094-2

o   Sci Transl Med 2019 Sep 25.              https://doi.org/10.1126/scitranslmed.aaw9414

o   Blood volume 136, Supplement 1 2020 Nov https://doi.org/10.1182/blood-2020-140007

o   Blood 2022 Mar 3                                              https://doi.org/10.1182/blood.2020008493

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here