POSTDOCTORAL ASSOCIATE - Immunology

Updated: 15 days ago
Location: Durham, NORTH CAROLINA

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Job Description:

Post-doctoral position in neuroimmunology for enthusiastic, hard-working individuals in Dr. Mari Shinohara’s laboratory at Duke University School of Medicine at Durham, North Carolina. The position is to investigate how the innate immune system impacts neuroinflammation in Alzheimer’s disease and/or multiple sclerosis (MS) using its animal model EAE. We will use various omics approaches, and those interested in single-cell transcriptomics techniques are also encouraged to apply. This project will emphasize complex mouse models, molecular and biochemical approaches, and immunological techniques. For more information on the Shinohara lab, please visit: https://sites.duke.edu/shinoharalab/

Here are recent publications from our laboratory:

  • Aggarwal, N., Deerhake, M. E., DiPalma, D., Shahi, S. K., Gaggioli, M. R., Mangalam, A. K. & Shinohara, M. L. (2021). Secreted osteopontin from CD4(+) T cells limits acute graft-versus-host disease. Cell Rep. 37: 110170. https://www.ncbi.nlm.nih.gov/pubmed/34965439
  • Barclay, W. E., Aggarwal, N., Deerhake, M. E., Inoue, M., Nonaka, T., Nozaki, K., Luzum, N. A., Miao, E. A. & Shinohara, M. L. (2022). The AIM2 inflammasome is activated in astrocytes during the late phase of EAE. JCI Insight. 7. https://doi.org/10.1172/jci.insight.155563
  • Deerhake, M. E., Danzaki, K., Inoue, M., Cardakli, E. D., Nonaka, T., Aggarwal, N., Barclay, W. E., Ji, R. R. & Shinohara, M. L. (2021). Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. Immunity. 54: 484-498 e488. https://www.ncbi.nlm.nih.gov/pubmed/33581044
  • Xu-Vanpala, S., Deerhake, M. E., Wheaton, J. D., Parker, M. E., Juvvadi, P. R., MacIver, N., Ciofani, M. & Shinohara, M. L. (2020). Functional heterogeneity of alveolar macrophage population based on expression of CXCL2. Sci Immunol. 5. https://www.ncbi.nlm.nih.gov/pubmed/32769172
  • Kanayama, M., Xu, S., Danzaki, K., Gibson, J. R., Inoue, M., Gregory, S. G. & Shinohara, M. L. (2017). Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nat Immunol.18: 973-984. https://www.ncbi.nlm.nih.gov/pubmed/28671690

Requirements:

Self-motivated individuals who have a PhD and/or MD. The ideal candidates should have a strong background in immunology and mouse disease models. Additional expertise in molecular biology, experimental neuroscience, or genomics is greatly advantageous. Experience in EAE is desirable.

Candidates will also develop skills in mouse models of autoimmunity and neurological disorders, immune function assays, flow cytometry, microscopy, biochemistry and molecular biology techniques. The candidate will also gain considerable experience writing manuscripts, reviews and grants along with oral presentations. Additional duties will include mouse colony management, training of undergraduate and graduate students, participation in department activities, presentations at lab, local and national meetings and any other assignments that the PI may request. Collaboration and working on multiple projects are highly encouraged.

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