Postdocs and Research Scientists in Bioinformatics and Multi-Omics Data Science at Yale University

Nature Careers, United States

Updated: about 1 month ago
Location: New Haven, CONNECTICUT
Job Type: FullTime

Postdoctoral and Associate Research Scientist positions in Bioinformatics, Multi-Omics Data Science and Computational Proteogenomics for Immunotherapy and Cancer Vaccine Research.

Postdoctoral and Associate Research Scientist Positions in Etienne Caron Lab at Department of Immunobiology, Yale School of Medicine. The Caron Lab seeks exceptional Postdoctoral and Associate Research Scientist candidates with a passion for innovation in immunotherapy and cancer vaccine research using computational proteogenomics and immunopeptidomics approaches.

The overarching goal of the Caron Lab is to develop and apply mass spectrometry-based immunopeptidomics and systems immunology approaches to understand the generation, composition and dynamics of both the self and nonself immunopeptidome, as well as its interaction with T cells, with the goal of innovating treatments and preventive strategies for a broad range of immune-related diseases.

Responsabilities:

  • Develop and apply computational pipelines and innovative bioinformatics approaches for the discovery of novel tumor-specific antigens, PTMs, and both canonical and non-canonical actionable T cell epitopes from large immunopeptidomics datasets,
  • Collaborate with other researchers (academic and industry).
  • Train other lab members,
  • Publish high impact factor publications,
  • Present in conferences, locally, nationally and internationally,
  • Actively contribute to the lab's activities, including preparation of manuscripts and research grants.

    • Qualifications:

  • Ph.D. in systems immunology, bioinformatics or related field,
  • Demonstrated expertise in the integration and analysis of large multi-omics datasets (WGS, RNAseq, ribo-seq, proteomics, immunopeptidomics),
  • Knowledge in T cell biology and neoantigen prediction using epitope prediction algorithms,
  • Demonstrated expertise in the development of computational pipelines and databases,
  • Strong publication track record (at least one first author paper in a high impact factor journal)
  • Strong communication skills in English (spoken and written),
  • Demonstrated excellence in time management and teamwork.

    • Opportunities and Benefits:

    The selected candidates will have the opportunity to gain expertise in mass spectrometry, systems immunology, spatial immunopeptidomics, T-cell epitope discovery, immunology, and vaccine design. The selected candidates will also have the opportunity to become active players within several Yale Centers, including the Yale Center for Immuno-Oncology (YCIO), Center for Infection and Immunity (CII), and Center for Systems and Engineering and Immunology (CSEI). Strong support will be given to pursue independent directions. Compensation and benefits will be according to Yale policies.

    About the Caron Lab:

    Dr. Caron is an Assistant Professor at Yale University. Over the last five years, the Caron Lab has published 14 immunopeptidomics manuscripts including 10 as corresponding papers in Journal of Experimental Medicine, Cell Systems, Cancer Discovery, and other high-profile journals. Dr. Caron is co-founder and former chair (2015-2020) of the Human Immunopeptidome Project. He has a total citation of >4400 times to date and is the recipient of multiple Awards and Recognitions. Please see https://medicine.yale.edu/profile/etienne-caron/  for more information.

    If interested, please send your CV and motivation letter to [email protected] .

    Yale University is an Affirmative Action/Equal Opportunity Employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected Veterans, and underrepresented minorities


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