Post-Doctoral Fellow/Research Scientist – Lynch Comprehensive Cancer Research Center Laboratory

Updated: about 2 months ago
Location: Omaha, NEBRASKA

Under direction of the Principal Investigator, final selected candidate will perform complex scientific research relevant to cancer biology and other pro-inflammatory diseases and conditions.  The role is a key member of the Lynch Comprehensive Cancer Research Center (LCCRC) and will lead and participate in research studies investigating the efficacy of novel therapeutic agents such as mimetic apolipoprotein peptides (currently under exploration) and others with high-impact antitumorigenic/anti-inflammatory therapeutic potential.  S/He will employ in vitro, in vivo, and ex vivo experimental models using commercial and primary cell-lines and tumor/biopsy tissues from human and murine sources to determine biological mechanisms associated with development and progression of cancer and other pro-inflammatory diseases/conditions.  This role is expected to be fully independent (requiring only minimal training/supervision for new methods/technologies) in performing essential experimental techniques such as cell culture, tissue processing and analysis, immunoassays (such as ELISA, flow cytometry, immunofluorescence), molecular biology techniques (such as Next Gen Sequencing, i.e., WGS, EGS, CGS, SNP analysis, and qPCR).  S/He is expected to be comfortable and competent in following all applicable biosafety regulations in working with biospecimens (i.e., blood, tissues, cells) deemed necessary for all assigned research.

 

The Post Doc will participate in overseeing basic functions of the laboratory including maintenance of equipment for tissue culture (incubators, centrifuges, freezers, liquid nitrogen) and inventorying/ordering/stocking of supplies (disposables, reagents, medium, cell lines).  S/He will mentor and guide students and technicians in research activities including performance of literature reviews relevant to current and future research projects and grant proposals and will lead and participate in manuscript and grant preparation and submission.  S/He will organize data for easy access and may perform any special projects as assigned by the Principal Investigator.  Candidates with a strong background in molecular immunology and/or molecular biology and/or related disciplines are strongly encouraged to apply.


Responsibilities - Ideal candidates will be expected to:
•    Lead existing research projects with regards to design, execution and analysis of experiments, and participate in guiding/mentoring students and technicians to complete assigned work within allotted time.
•    Establish independent research projects, present at scientific meetings, and author peer-reviewed publications.
•    Demonstrate ability and desire to develop grantsmanship skills for the preparation of competitive funding proposals
•    Form part of multidisciplinary research collaborations; leverages synergy among different laboratories to facilitate the investigation of highly innovative and underexplored questions
•    Contribute to training/supervision of students and technicians in the LCCRC Laboratory
•    Participate in oversight of the maintenance of the laboratory.


Depending upon qualifications of final candidate they will be extended either a Postdoctoral Research Fellow and/or a Research Scientist position.  


This position will work Monday to Friday; 8am-4:30pm; depending upon research needs position may require evening, weekend, and holiday work.

 
This is 100% grant funded. 
 


Research Scientist summary:
The Research Scientist provides essential counsel in experimental design, statistical analysis, and clinical care while working collaboratively with other researchers, technicians, trainees and other Primary Investigators.  The Research Scientist will promote his/her supervisor's research program by conducting research studies and presenting findings.   
  
Qualifications for a Research Scientist:
Doctoral degree or equivalent in related field of study;
Seven (7) years of research experience in related field and/or 3 years of experience as a postdoctoral researcher;
Experience in sterile technique for cell culture with BSL-2+ practices, exceptional skills in cell culture models;
Prior experience with biopsy tissue processing and analysis and cell culture models with primary cells is strongly preferred;


Knowledge, Skills, Abilities for a Research Scientist:
Knowledge of concepts and practices in field of study;
Skill in using scientific rules and methods to solve problems;
Skill in using logic and reasoning to identify the strengths and weaknesses of alternative solutions, conclusions or approaches to problems;
Must be familiar with multi-color flow cytometry (staining, gating, analysis using software);
Must be comfortable working with BSL2+ biospecimens (cells, plasma, tissue biopsies) from patients with cancer and/or other pro-inflammatory diseases or conditions;
Preferred qualifications (not required): ELISA, immunofluorescence, Next Gen sequencing, qRT-PCR, Western Blot, and other molecular biology techniques; mouse experience and animal procedures (phlebotomy, injections, tissue dissections) are strongly preferred but not required;


Postdoctoral Research Fellow summary:
A postdoctoral scholar "postdoc" is an individual holding a doctoral degree who is engaged in a temporary and defined period, typically less than 5 years, of mentored research and/or advanced scholarly training for the purpose of acquiring the professional skills needed to pursue a career path of his/her choosing. Performs research under the supervision and mentorship of a more senior researcher, often called the postdoctoral advisor. Provides senior-level technical lab support by designing and performing experiments and research related tasks.  Evaluates experiment results using complex statistical and multivariate analysis.  Prepares data for publication and assists in writing grant proposals.

  
Qualifications for a Postdoctoral Research Fellow:
Doctorate Degree;  
1-3 years' experience in sterile technique for cell culture with BSL-2+ practices, exceptional skills in cell culture models;
Prior experience with biopsy tissue processing and analysis and cell culture models with primary cells is strongly preferred;


Knowledge, Skills, Abilities for Postdoctoral Research Fellow:  
Must be familiar with multi-color flow cytometry (staining, gating, analysis using software);
Must be comfortable working with BSL2+ biospecimens (cells, plasma, tissue biopsies) from patients with cancer and/or other pro-inflammatory diseases or conditions;
Preferred qualifications (not required): ELISA, immunofluorescence, Next Gen sequencing, qRT-PCR, Western Blot, and other molecular biology techniques; mouse experience and animal procedures (phlebotomy, injections, tissue dissections) are strongly preferred but not required;
Strong ability to interpret data and to troubleshoot and resolve technical issues; 
Strong work ethic, excellent written and communication skills, and the ability to work independently;
Proficiency in Microsoft Office Suite to include Word, Excel; PowerPoint and Outlook;
Ability to work evenings, weekends, and holidays depending upon research needs


Physical Requirements for either role:
Seeing: 75 – 100%
Hearing: 75-100%
Standing/Climbing/Mobility: 50-74%
Lifting/Pulling/Pushing: 25-49% (pound: 20lbs.)
Fingering/Grasping/Feeling: 75-100%
Travel: 0-24%
Exposure to Blood Borne pathogens: Yes
Working with Animals: Yes (rodents)
AAP/EEO Statement:
Creighton University is committed to providing a safe and non-discriminatory educational and employment environment. The University admits qualified students, hires qualified employees and accepts patients for treatment without regard to race, color, religion, sex, marital status, national origin, age, disability, citizenship, sexual orientation, gender identity, gender expression, veteran status, or other status protected by law. Its education and employment policies, scholarship and loan programs, and other programs and activities, are administered without unlawful discrimination.
Disclosure Statement:
This description describes the general nature of work to be performed and does not include an exhaustive list of all duties, skills, or abilities required. Regular, reliable attendance is an essential function and all employees are required to follow any other job-related instructions and to perform any other job-related duties as requested by their supervisor. Employees may also be required to work in excess of normal working hours as workloads and seasonal activities necessitate. A complete description is available in the Human Resource office located at 3006 Webster Street Omaha, NE. Creighton University reserves the right to modify duties, responsibilities and activities at any time with or without notice.

 

 


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