Post-Doctoral Associate(s)

Updated: 8 months ago
Location: New Brunswick, NEW JERSEY

Position Details

Position Information

Recruitment/Posting Title Post-Doctoral Associate(s)
Department SASN - Biological Sciences
Salary Open
Posting Summary

The Dobrowolski laboratory, Department of Biological Sciences, Rutgers University-Newark, seeks two Post-Doctoral Associates in Disease Modeling, Nuclear Architecture, and Molecular Clearance to begin January 1, 2020 through December 31, 2020, renewable annually.

We are searching for motivated recent Ph.D. graduates with strong interest in molecular mechanisms of human neurodegenerative diseases and experience in protein biochemistry (western blots, immunodetection), confocal microscopy, cloning, and iPSC cell culture. Candidates experienced in stem cell biology, CRISPR/Cas9 techniques, and advanced confocal microscopy are particularly encouraged to apply for the following projects.

Determining mechanisms by which Alzheimer disease (AD)-associated mutations in presenilin, tau, and other genes affect nuclear calcium signaling that regulates molecular clearance pathways (autophagy, endocytosis, lysosomal degradation, etc).
Testing the hypothesis that cellular aging and AD-related changes in nuclear morphology affect RNA and regulatory protein shuttling in and out of the nucleus driving brain aging and promoting disease onset.

Both projects will be realized using available CRISPR/Cas9-edited human iPSC-derived cells (neurons, astrocytes, and other) and novel optogenetic tools that disrupt nuclear architecture and signaling. Live-cell imaging and a variety of novel as well as conventional cell biological methods will be used to realize these projects.

The principal focus of research is on the molecular mechanisms leading to neuronal death in Alzheimer and Parkinson disease. We have recently identified novel intracellular signaling cascades that regulate the autophagy-lysosomal pathway and molecular clearance. The long-term goal of our laboratory is to define changes in major cellular signaling pathways (mTOR and others) regulating RNA and protein stability and their degradation. We investigate these alterations in vivo in mouse and Drosophila models, and in vitro in several isogenic human iPSC derived cell types.

Posting Number 19FA2054
Posting Open Date 09/16/2019
Posting Close Date 11/15/2019


Minimum Education and Experience

Ph.D. in molecular cell biology with experience in stem cell culture.

Required Knowledge, Skills, and Abilities
Equipment Utilized
Physical Demands and Work Environment

Laboratory environment.


The School of Arts and Sciences-Newark (SASN) is a place where exploration, discovery, and imagination come together to form the core of a liberal arts education. We serve all undergraduates at Rutgers University-Newark (RU-N); and offer a broad selection of more than 2,000 undergraduate and graduate courses a year in more than 40 subjects. SASN combines the best of a large research university with a small liberal arts college. RU-N is a remarkably diverse, urban, public research university that is not just in Newark, but of Newark-an anchor of our home city.


Posting Details

Special Instructions to Applicants

Applicants should provide a curriculum vitae and the names and contact information of three references.

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Campus Rutgers University-Newark
Home Location Campus Rutgers University-Newark
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