Post-Doctoral Associate, Neuro-Oncology

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The Sylvester Comprehensive Cancer Center has a great opportunity for a Postdoctoral Research Associate Neuro-Oncology. The Iavarone Lab is seeking an outstanding candidate for a Postdoctoral Research position to join the system biology and bioinformatics team. The Iavarone Lab studies brain tumors and his group develops and applies computational and systems biology approaches to dissect the molecular mechanisms that drive brain tumorigenesis, the composition tumor microenvironment in distinct subtypes of tumors and therapy resistance. The candidate will analyze and integrate high-throughput multiomics data including transcriptomic, genomic, epigenomic, functional genomic, chemical genomic and proteomic data from bulk tumors and single-cells to model context-specific cellular/molecular networks and identify actionable targets, biomarkers that could be utilized for the development of precision medicine in patients with brain tumors.

The Iavarone Lab provides a highly interactive environment with projects involving basic and clinical research collaborators, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. Innovative research will be supported by the lab’s infrastructure, including a state-of-the-art wet lab for experimental validation. As a member of the lab the candidate will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings.

Candidates with expertise in oncology, mining algorithms, big data mining, machine learning, bioinformatics and design, analysis, implementation, and experimental evaluation are encouraged to apply.

Experience with omics data analysis using R or Python and familiarity with linux/unix is required. Experience and knowledge in chemical biology, network biology, parallel computing, web development and visualization is also highly desirable.  Candidates are expected to exercise independent discretion and judgment in carrying out research activities and develop methods of research.

Requirements:
Education: PhD in Computational Biology, Bioinformatics, or a related field preferred. MD or Ph.D. in relevant field required.

Experience: No prior experience required.  First Author Scientific Publications preferred.

Knowledge, Skills, and Attitudes:

•Skill in collecting, organizing, and analyzing data.

•Ability to recognize, analyze, and solve a variety of problems.

•Ability to exercise sound judgment in making critical decisions.

Work from the labs includes:

Garofano L et al . Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities. Nature Cancer  Feb;2(2):141-156; doi: 10.1038/s43018-020-00159-4, 2021. [see also Hubert, C.G. and Lathia J.D. Seeing the GBM diversity spectrum. Nature Cancer , Feb;2(2):135, 2021].

Lee SB  et al. Proline Hydroxylation Primes protein kinases for autophosphorylation and activation. Mol. Cell  79:376-389, 2020.

*D’Angelo F.  et al. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nature Medicine , 25:176-187, 2019

Frattini V et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature , 553: 222–227, 2018. Nature , 553: 222–227, 2018; [see also RESEARCH WATCH “FGFR3–TACC3 Activates Mitochondrial Respiration via PIN4 Phosphorylation” Cancer Discovery Published Online First January 12, 2018 doi: 10.1158/2159-8290.CD-RW2018-008; RESEARCH HIGHLIGHTS “Fusion Power” Nature Reviews Cancer Published online January 25, 2018 doi:10.1038/nrc.2018.2; NATURE.COM/PATHOLOGY “Gene fusions in cancer metabolism” Laboratory Investigation 98:271, 2018].

Lee SB  et al. An ID2-dependent-mechanism for VHL inactivation in cancer. Nature  (Article), 529:172-177, 2016; [see also RESEARCH WATCH “Hypoxia promotes cancer stem cells via ID2-dependent VHL inactivation” Cancer Discovery (6: 120, 2016). RESEARCH HIGHLIGHTS “Pathway to stemness” Nature Reviews Cancer (16: 70, 2016)]

Interested candidates please apply online and in addition you may also send your CV to [email protected]

The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

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Job Status:

Full time

Employee Type:

Staff

Pay Grade:

A9