Post-Doc Research Associate Li-Maeda Lab

University of North Carolina, United States

Updated: about 2 years ago
Location: Chapel Hill, NORTH CAROLINA
Job Type: FullTime
Deadline: ; ;

Posting Information
Department Pathology Lab Med - Research - 413804
Posting Open Date 01/24/2022
Application Deadline
Open Until Filled Yes
Position Type Postdoctoral Scholar
Position Title Post-Doc Research Associate Li-Maeda Lab
Vacancy ID PDS003343
Full-time/Part-time Full-Time Temporary
Hours per week 40
FTE 1
Work Location Chapel Hill, NC
Position Location North Carolina, US
Hiring Range $47,476 to $52,500
Proposed Start Date
Estimated Duration of Appointment 12 Months

Primary Purpose of Organizational Unit
The UNC School of Medicine has a rich tradition of excellence and care. Our mission is to improve the health and wellbeing of North Carolinians, and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research. We strive to promote faculty, staff, and learner development in a diverse, respectful environment where our colleagues demonstrate professionalism, enhance learning, and create personal and professional sustainability. We optimize our partnership with the UNC Health System through close collaboration and commitment to service. 
OUR VISION
Our vision is to be the nation’s leading public school of medicine. We are ranked 2nd in primary care education among all US schools of medicine and 5th among public peers in NIH research funding. Our Allied Health Department is home to five top-ranked divisions, and we are home to 18 top-ranked clinical and basic science departments in NIH research funding.
OUR MISSION
Our mission is to improve the health and well-being of North Carolinians and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research.
Patient Care: We will promote health and provide superb clinical care while maintaining our strong tradition of reaching underserved populations and reducing health disparities across North Carolina and beyond.
Education: We will prepare tomorrow’s health care professionals and biomedical researchers by facilitating learning within innovative curricula and team-oriented interprofessional education. We will cultivate outstanding teaching and research faculty, and we will recruit outstanding students and trainees from highly diverse backgrounds to create a socially responsible, highly skilled workforce.
Research: We will develop and support a rich array of outstanding health sciences research programs, centers, and resources. We will provide infrastructure and opportunities for collaboration among disciplines throughout and beyond our University to support outstanding research. We will foster programs in the areas of basic, translational, mechanistic, and population research.
Position Summary
A postdoctoral research fellow is sought in the joint laboratory of Dr. Feng Li and Dr. Nobuyo Maeda from the Department of Pathology and Laboratory Medicine at the University of North Carolina – Chapel Hill. Our research aims to gain mechanistic insights into how quantitative variants of some genetic factors modulate the severities of cardiovascular complications induced by common disease conditions such as hyperglycemia, hyperlipidemia and/or hypertension. We utilize mouse models in which the expression of a given gene vary within the physiological range (30%-300%), and through treating the enhanced disease models with commonly used nutritional/natural substances whose safeties are already well established. One such example is the use of nicotinamide (vitamin B3) for the prevention of preeclampsia, a hypertensive disorder during pregnancy, modeled by a hypermorph of the Edn1 gene encoding Endothelin1. The other is a high-dose oral cyanocobalamin (vitamin B12) for the prevention of diabetic cardiomyopathy and diabetic nephropathy, the severities of which are profoundly affected by the quantitative variants of the Elmo1 (Engulfment and Cell Motility) gene. Specific research topics for the fellow include, but not limited to, (1) the role of vitamins in enhancing cellular antioxidant defense systems such as those involving Nef2l2 (coding for NRF2, nuclear factor 2), and (2) the relationships between the quantitative variants in the expression of Elmo1 and the severities of hypertension associated cardiovascular/kidney disease.
Minimum Education and Experience Requirements
Ph.D. in the biological sciences, such as molecular or cellular biology, biochemistry, clinical or medical laboratory science, or related areas, or an equivalent professional degree such as an MD, DO, or DVM
Required Qualifications, Competencies, and Experience
Candidates must have experience with hands-on research and knowledge of molecular genetics. Candidates must possess excellent scientific writing and communication skills demonstrated by published papers and presentations.
Preferred Qualifications, Competencies, and Experience
Candidates should demonstrate high motivation and enthusiasm for research in medical science. Beneficial to have experience with molecular genetics mouse experiments.
Special Physical/Mental Requirements
Special Instructions
Interviewed candidates will be required to present two letters of reference before an offer may be extended.  One should be from the PhD mentor of the applicant.
For information on UNC Postdoctoral Benefits and Services click here
Quick Link https://unc.peopleadmin.com/postings/220518

Department Contact Name and Title Blake Burklin, HR Consultant
Department Contact Telephone or Email [email protected]
Postdoctoral Affairs Contact Information

If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at (919) 966-3576 or send an email to [email protected].

Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.
Equal Opportunity Employer Statement
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.

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