Open Postdoctoral position, faculty mentor Mark Mercola

Applications are invited for a Postdoctoral Research Scientist to work with Professor Mark Mercola investigating new strategies and therapeutic targets for heart failure using iPSC and animal models. This project is part of NIH funded grants to develop technology for cardiac drug discovery and elucidating novel therapeutic candidates in collaboration with investigators at Stanford University (Euan Ashley, Jesse Engreitz, Ioannis Karakikes, Thomas Quertermous) and the University of California (Shankar Subramaniam).
The overall project is to comprehensively define therapeutic target space for cardiomyopathies using patient and CRISPR-engineered human iPSC models and high throughput physiological recording to achieve our goal of developing mechanism-based therapeutics. Projects involve large scale functional genomics screening to reveal candidate therapeutic targets and target validation using in vitro models, human genetics, and animal testing.
Postdoctoral fellows will perform cellular and molecular studies using automated screening instrumentation to discover novel therapeutic targets and strategies, and validate finding in relevant animal models (e.g., using AAV gene perturbation). In addition, postdoctoral fellows will will aid in supervising and training of students and technicians. The successful applicant will be expected to present at internal group meetings and will have the opportunity to attend external scientific meetings and draft manuscripts for publication. There will be scope for further research training through courses run at Stanford University and for developing independent research programs with independent funding, for instance NIH or American Heart Association career development awards.
The successful applicant will hold or be near to completion of a relevant PhD degree, and have experience in one or more of the following areas: iPSC disease modelling, molecular genetics, or cardiovascular physiology. The successful applicant must be strongly motivated with a highly enthusiastic approach to science and good organizational, verbal, communication, and interpersonal skills. They must be able to work both independently and part of a research team. Experience with coding in R, histology and immunohistochemistry, CRISPR gene editing, and cardiomyocyte physiology are desirable but not required.
The successful applicant will be based in the new Biomedical Innovation Building centrally located on the Stanford campus and have access to facilities for training and recreation.
Interviews are likely to be held during the first quarter of 2024.