Updated: 15 days ago
Location: Durham, NORTH CAROLINA

School of Medicine:

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Department of Neurosurgery, Duke School of Medicine
Occupational Summary

100% Grant funded

A Lab Research Analyst 1 position is available in the Departments of Neurosurgery and Pharmacology and Cancer Biology at Duke University. We are seeking motivated individuals to investigate mechanisms of metastatic progression to the bone and spine. The successful candidate will work in a collaborative environment with other scientists in the Departments of Neurosurgery, Pharmacology and Cancer Biology, and the Duke Center for Brain and Spine Metastasis. This position will specifically 1) investigate the genetic and epigenetic alterations associated with metastatic spine disease, 2) characterize tumor-specific, tumor microenvironment associated changes and immune cell changes in hormone-responsive cancers using molecular approaches with the goal of characterizing novel biomarkers and signatures associated with metastatic spine disease.

The position will also aid the overall research program spanning bench to bedside with a multidisciplinary team within surgery, radiation oncology, medical oncology, and palliative care. Key features of this role include (1) coordination, growth and development of the program’s translational research portfolio, (2) grant writing assistance for local, federal and/or foundation grants pertinent to the program, and (3) oversight of clinically-annotated banked tissues from patient samples treated at Duke for brain and spine metastases.

Duties and responsibilities include:

• Carry-out literature review to guide research. • Perform standard technical procedures such as PCR, qPCR, and electrophoresis, etc. • Perform DNA extraction from human clinical specimens, fresh-frozen and/or paraffin-embedded tissue and aid in execution of experimental design and analysis of next generation sequencing data. • Organize and perform integrative analysis of complex genetic and morphologic data, including computational and/or statistical analysis.

• Perform vivo experiments of metastasis using subcutaneous, tail vein injection, intracardiac, and other orthotopic animal models. • Establish and execute a validation/verification plan in light of biomarker discovery.

• May assist with drafting LOI’s, (2) preparing IRB applications, (3) preparing budgets, (4) interfacing with industry or foundation partners to develop concepts, (5) submitting protocols for scientific and regulatory review, (6) helping process amendments, (7) assisting with abstract, posters, and manuscript drafts (including reference management and submission of materials).

• Position will be involved in training and education of neurosurgery residents, medical and graduate students in the School of Medicine, and undergraduates under the leadership of the Director of Metastatic Spine Tumor.


Work requires two years of research experience. A related master's or an equivalent combination of relevant education and/or experience/degree may offset required years of experience on a 1:1 basis, e.g., a two-year master's degree in lieu of two years of experience.

Candidates with interest in clinical diagnostic molecular genetics, expertise in tumor biology and/or animal models of metastasis are encouraged to apply. The position entails a one- to three-year period, with extension contingent on performance and funding.

· Ability to perform molecular & cellular protocols and mouse models, cloning, mutagenesis, standard biochemistry for protein analysis, viral-based protocol.

· Qualifying competencies include excellent oral and written communication skills.

· Excellent organizational skil

Minimum Qualifications

Work requires a bachelor's degree in botany, biology, zoology, psychology or other directly related scientific field.


Work requires two years of research experience. A related master's OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE degree may offset required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience.

Knowledge, Skills and Abilities


Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

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