LAB RESEARCH ANALYST I

Updated: 12 months ago
Location: Durham, NORTH CAROLINA
Deadline: The position may have been removed or expired!

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Position is expected to start no earlier than 8/1/23.

1. Conduct a variety of investigations in the planning, development and implementation of experimental procedures and specialized imaging assays for DNA damage response. Collect information and data through observation, experimentation and various other methods, to include operating highly technical laboratory instruments and equipment e.g., confocal microscope.

The work includes, but is not limited to:

Examine the effects of anti-cancer compounds using cancer cell lines and xenograft in animal model;

Monitor the tumor growth rate in animal model using bioluminescence imaging;

Determine the target protein expression level in cancer cell lines and animals’ tumors using IHC staining;

Utilize the following analytical and photo imaging software:

Analytical software: Image J and GraphPad Prism; Photo imaging software: Olympus Imaging Software and Chemiluminescence;

Summarize weekly research outcomes and data analysis into reports;

Most importantly, this position requires comprehensive knowledge of microscope and experience in handling mouse model. This person must be able to lead and perform independent tumor studies in cancer cell lines and mouse model without supervision. They must be able to work with different tumor cells and perform xenograft (the transplant of an organ, tissue, or cells to an individual of another species), tumor injection, inhibitors injection, daily monitoring, surgery in mice, tumor dissection and staining.  

2. High-throughput compound screening. Performing and analyzing chemical screens. Assist facility users to design, troubleshoot, perform and analyze high throughput compound screens. Act as coordinator to organize and schedule multiple screens simultaneously.

The work includes, but is not limited to:

- Screening the effects of the compound library using a DART assay;

-Research and develop methodologies to dissolve the compounds and to test their bioavaibility/absorption rate;

-Determine compound-target interaction using MST and SPR assays;

-Investigate synergetic effects between candidate compounds and FDA-approved medications;

-Provide and summarize dataset from screening.

3. Perform lab administrative tasks such as ordering and lab organization.

4. Supervise, train and instruct students or lower level personnel in laboratory techniques and procedures.


Minimum Qualifications
Education

Work requires a bachelor's degree in botany, biology, zoology, psychology or other directly related scientific field.


Experience

Work requires two years of research experience. A related master's OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE degree may offset required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience.

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.



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