Improving Efficacy through New Measurements and Classical Design

RAP opportunity at National Institute of Standards and Technology     NIST

Improving Efficacy through New Measurements and Classical Design

Location

Material Measurement Laboratory, Materials Measurement Science Division

opportunity location
50.64.31.B8437 Gaithersburg, MD

NIST only participates in the February and August reviews.

Advisers
name email phone
John Michael Pettibone [email protected] 301.975.5656
Description

The Nanomaterials Research Group is interested in developing analytical methods to foster improved design of nanoparticle-based therapeutics. The design principles to optimize the stability, targeting, and delivery of drugs using nanoparticles requires a thorough understanding of the roles the NP core (e.g., size, shape, composition, etc.) and surface properties contribute for both targeted delivery and efficacy. To address problems associated with characterization and quantification of the drug load as they relate to efficacy, the ability to measure the distribution of drug states present (free, bound, aggregated, etc.) is a primary objective. Thus, a tiered approach, whose basis is in the ability to characterize the (interfacial) properties of the nanoparticle systems and measure the distribution of different drug forms present in relevant media, will be implemented to progress current understanding of in vivo results.

key words

Drug delivery; Nanoparticle; Interfacial chemistry; Analytical chemistry; Mass spectrometry; Fluorescence, Separation;

Eligibility

Citizenship:  Open to U.S. citizens

Level:  Open to Postdoctoral applicants

Stipend
Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00