Functional Genetic Analysis of Cancer

Updated: 4 days ago

Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD and surrounding area

Position Description:

The Functional Genetics Section (Genetics Branch, CCR, NCI) conducts multidisciplinary research using functional genetic approaches coupled with molecular, biochemical, and cell biology-based methods to interrogate the genetic, transcriptional, and cell-signaling alterations observed in cancer cells. Our current research focuses on cancers driven by fusion oncoproteins. One aspect of our research program is studying the reprogramming of the transcriptome and signaling networks by fusion transcription factors. We are seeking a motivated candidate interested in the study of the changes in the transcriptome and signaling networks in a fusion transcription factor-driven cancer that influence cell-cell and cell-matrix interactions. The successful applicant will apply molecular, biochemical, and cellular approaches to assess the function of selected genes-of-interest involved in the regulation of cell-cell and cell-matrix interactions. We work with many other investigators within the intramural program and take advantage of the uniqueness of the CCR intramural program in that our studies span fundamental discovery through preclinical translational research, as well as CCR’s many core facilities. The CCR also offers many career development opportunities for scientists early in their careers.


We are seeking self-motivated candidates with Ph.D. or M.D. degree, or equivalent, in molecular/cell biology or biochemistry, or related disciplines, ideally with additional training in transcription factor biology. Applicants should have demonstrated a record of accomplishment, as evidenced by at least one first-author paper and a commitment to performing cancer research at the highest level. Prior experience growing cancer cells in 3D-format will be advantageous, as will experience applying genome or transcriptome-scale analysis methods. The candidate must have excellent organizational and communication skills and fluency in both verbal and written English.

To Apply:

Please email CV, Bibliography, a brief statement of research interests, and the names of three references to [email protected] .

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.

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