<!--anchor--> <!--anchor--> Postdoctoral Fellow – RNA Chemical Modification Sequencing, Goyon Lab <!--anchor-->

We have an opening for a highly passionate postdoctoral fellow with a strong background in RNA sequencing, including RNA chemical modifications, and structure determination. The fellow will join the Genentech Research and Early Development (gRED) organization. Research endeavors will involve: i) the development of a platform technology for the direct sequencing of therapeutic RNAs and their chemical modifications; ii) understanding of chemical modification effect on RNA function and stability; iii) identification and quantification of chemically modified RNA molecules naturally occurring in biological matrices. The successful candidate will have the access to direct sequencing technologies including Nanopore and multi-dimensional liquid chromatography coupled to mass spectrometry (mD-LC-MS), and the opportunity to work in a highly collaborative cross-functional environment.

Who you are:

• Candidates must have a PhD in RNA analytical, biochemical, biomedical engineering, or a related field.
• Have one or more first-author publications in high quality journals.
• Experience with the sequencing of RNA, including their modifications, and structure determination (Nanopore is preferred).
• Experience with biophysical characterization methods for protein-nucleic acid interactions and genome editing performance (such as the CRISPR/Cas9 technology) or in vitro assay development are beneficial.
• Practical knowledge of computational data analysis tools is desired.
• Pragmatic and focused researcher, driven to solve complex scientific problems independently and in a collaborative environment.
• Efficient oral and written communication skills are required.

More Information about the Genentech Postdoctoral Program:
http://www.gene.com/careers/academic-programs/postdocs

For more information about Goyon Lab:

https://www.gene.com/scientists/our-scientists/alexandre-goyon

Relevant publications:

J. D. Alfonzo, J. A. Brown, P. H. Byers, V. G. Cheung, R. J. Maraia & R. L. Ross, A call for direct sequencing of full-length RNAs to identify all modifications, Nat. Gen. 53, 2021, 1113-1116.

A. Goyon, B. Scott, K. Kurita, C. M. Crittenden, D. Shaw, A. Lin, P. Yehl, and K. Zhang, Full Sequencing of CRISPR/Cas9 Single Guide RNA (sgRNA) via Parallel Ribonuclease Digestions and Hydrophilic Interaction Liquid Chromatography–High-Resolution Mass Spectrometry Analysis, Anal. Chem. 93, 2021, 44, 14792–14801

W. Stephenson, R. Razaghi, S. Busan, K. M. Weeks, W. Timp, and P. Smibert, Direct detection of RNA modifications and structure using single-molecule nanopore sequencing, Cell Genom. 2, 2022, 2, 100097

Relocation benefits are available for this position

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The expected salary range for this position based on the primary location of California is $64,000 and $120,300.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.