Senior Scientist in Rare Diseases & Structural Biology

We are seeking a highly motivated Senior Scientist to join the new Centre for Medicines Discovery at the University of Oxford. The successful candidate will initially join the group of Alex Bullock and contribute to existing drug discovery programmes, but will also be encouraged to secure future funding to establish their own independent research group catalysing the development of new medicines for rare diseases.

Initially, your work will support an EU-funded project, “EUbOpen”, which involves 22 partners from academia and industry and will involve significant collaborative teamwork. EUbOpen aims to generate chemical inhibitors for druggable protein families, including ubiquitin ligases (E3s) and solute carriers (SLCs). E3s are newly identified targets for small molecule PROTACs that recruit proteins of interest for targeted protein degradation (see Nat Rev Drug Discov.18(12):949-963). The project involves multi-disciplinary work spanning structural, chemical and cellular biology and seeks applicants with an outstanding track record in one or more of these areas. You will help to shape research plans, conduct lab research and contribute to the supervision of a small team of staff and students.

It is essential that you hold a PhD and a strong postdoctoral track record in academia and/or industry in structural, chemical or cellular biology relevant to the post. You will contribute to regular project meetings so will need excellent communication and project management skills, as well as an aptitude for team leadership to mentor and inspire junior researchers.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. 

This post is offered full-time on a fixed term contract until 30 April 2025, and is funded by the Innovative Medicines Initiative.

Please quote 151308 on all correspondence. Only applications received before 12.00 noon on 18 August 2021 will be considered.