Senior Research Associate

We are seeking to appoint a creative and experienced Senior Research Associate to study haematopoiesis using single-cell technologies.

Stem cells play a crucial role in maintaining the body's ability to replenish cell types as needed. The continuous generation of blood cells is essential for good health, this task is entrusted to blood-forming (hematopoietic) stem cells. Understanding how haematopoietic stem cell activities are regulated is highly sought-after. The Taoudi laboratory is at the forefront of this pursuit, employing advanced imaging techniques such as 3D and 4D quantitative imaging, single-cell gene expression analysis, and cutting-edge clonal tracking technology.

The successful candidate will largely focus on the biology of stem cells, specifically how they are formed, maintained, and how they sustain platelet production. The post will be based in the Taoudi laboratory at The School of Cellular and Molecular Medicine. This opportunity capitalizes on the recent advancements in technology and biology published by the Taoudi laboratory (https://www.nature.com/articles/s41467-022-35744-x) to investigate blood stem cell formation. Ideally, the successful candidate would start in May 2024.

• Extensive knowledge and practical experience in developmental biology (including microdissection), haematopoiesis, stem cell biology, and the use of research models.
• Direct experience with cell purification techniques (including flow cytometry, magnetic separation, membrane filtration).
• Experienced in general molecular (e.g., PCR and qRT-PCR) and imaging (e.g., confocal microscopy) techniques.
• Experience in the generation and analysis of single-cell gene expression datasets.
• Experience in the development and use of in vivo cellular barcoding technologies.
• Experience in the use of advanced statistical packages and/or coding for the analysis of next-generation sequencing data.
• Independently design and complete experimental plans.
• Experience in the co-supervision of PhD students.
• Contribution to grant preparation.
• Dissemination of research via contribution to manuscript writing, presenting talks and posters.

For informal enquiries please contact Samir Taoudi ([email protected]).  The closing date is 11:59pm on Sunday 17th March 2024 and interviews will be held on Monday 25th March 2024.

We recently launched our strategy  to 2030 tying together our mission, vision and values.

The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive and reach their full potential. We want to attract, develop, and retain individuals with different experiences, backgrounds and perspectives – particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution.

We are seeking to appoint a creative and experienced Senior Research Associate to study haematopoiesis using single-cell technologies.

Stem cells play a crucial role in maintaining the body's ability to replenish cell types as needed. The continuous generation of blood cells is essential for good health, this task is entrusted to blood-forming (hematopoietic) stem cells. Understanding how haematopoietic stem cell activities are regulated is highly sought-after. The Taoudi laboratory is at the forefront of this pursuit, employing advanced imaging techniques such as 3D and 4D quantitative imaging, single-cell gene expression analysis, and cutting-edge clonal tracking technology.

The successful candidate will largely focus on the biology of stem cells, specifically how they are formed, maintained, and how they sustain platelet production. The post will be based in the Taoudi laboratory at The School of Cellular and Molecular Medicine. This opportunity capitalizes on the recent advancements in technology and biology published by the Taoudi laboratory (https://www.nature.com/articles/s41467-022-35744-x) to investigate blood stem cell formation. Ideally, the successful candidate would start in May 2024.

• Extensive knowledge and practical experience in developmental biology (including microdissection), haematopoiesis, stem cell biology, and the use of research models.
• Direct experience with cell purification techniques (including flow cytometry, magnetic separation, membrane filtration).
• Experienced in general molecular (e.g., PCR and qRT-PCR) and imaging (e.g., confocal microscopy) techniques.
• Experience in the generation and analysis of single-cell gene expression datasets.
• Experience in the development and use of in vivo cellular barcoding technologies.
• Experience in the use of advanced statistical packages and/or coding for the analysis of next-generation sequencing data.
• Independently design and complete experimental plans.
• Experience in the co-supervision of PhD students.
• Contribution to grant preparation.
• Dissemination of research via contribution to manuscript writing, presenting talks and posters.

For informal enquiries please contact Samir Taoudi ([email protected]).  The closing date is 11:59pm on Sunday 17th March 2024 and interviews will be held on Monday 25th March 2024.

We recently launched our strategy  to 2030 tying together our mission, vision and values.

The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive and reach their full potential. We want to attract, develop, and retain individuals with different experiences, backgrounds and perspectives – particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution.