Research Technician LMS - 1387

Updated: about 1 month ago
Location: London, ENGLAND
Deadline: 22 Oct 2020

View Vacancy -- Research Technician LMS - 1387
Open Date
02/10/2020, 11:15
Close Date
22/10/2020, 23:55

MRC London Institute of Medical Science

The LMS is an Institute funded by the MRC and is a Division of the Faculty of Medicine, Imperial College. Based on the Hammersmith Hospital Campus in West London (W12), the LMS has first class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the established clinical base of Imperial College. For more information, visit .

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 5


£30,227 - £35,791 p.a. inclusive

Fixed Term

Technical & Scientific Professionals

Full Time

2 years

Overall purpose:

The ultimate goals of the group are to define new biology, to identify new biomarkers and drug targets and to translate scientific tools developed in the laboratory for patient benefit. We combine physiology, imaging, genetics and cell biology to investigate mechanisms underlying cardiovascular disease with a special interest in the role of interleukin 11 (IL11).

The post holder will investigate molecular mechanisms underlying cardiovascular disease using a range of in vitro models and studies using of model systems. Experiments will focus on cellular biology of cardiovascular cells from patients and model systems and on physiological processes in the heart. Specific emphasis will be placed on studies of the cardiac fibroblasts and myocytes and their effects on cardiac morphology and function. Use of transgenic lines is a key part of this work.

Main duties / key responsibilities:

  • Developing the Group’s model systems and phenotyping infrastructure and application of these techniques in model systems
  • To maintain transgenic lines including colony maintenance, breeding programmes and in vivo work performed within the group
  • Development and application of laboratory capabilities in molecular and cellular biology and high throughput phenotyping
  • Routine molecular and cellular biology techniques (PCR, QPCR, Western blotting, genotyping

The appointee will:

1)    Conduct research as part of the group’s core program

2)    Take an active part in the academic activities of the Group including group meetings, group journal clubs, training and organisational aspects

This is an MRC Lab Assistant position to support post-doctoral scientists in early or changed career training and to help establish them as successful research scientists in their chosen field. We offer a highly attractive benefits package including competitive salary and excellent holiday entitlement.

 Working relationships:

The post-holder will report directly to the head of the Group, Prof Stuart Cook.

Education / Qualifications / Training required (will be assessed from application form and at interview):


  • BSc or equivalent qualification in molecular or cellular biology


  • MSc or MRes in molecular or cellular biology in the cardiovascular science or a related discipline
  • Possesion of a Personal Home Office Animal License

Previous work experience required (will be assessed from application form and at interview):


  • Background in rodent physiology and colony maintenance
  • Experience working with transgenic mice including breeding and genotyping      
  • Experience with one or more of: molecular biology, basic cell biology, histology and the use of primary cells.
  • Background in tissue collection and process for molecular biology techniques
  • Basic skills in protein and RNA detection and/or cell biology


  • Evidence of understanding of cardiovascular physiology and disease
  • Understanding of cardiovascular disease

Knowledge and experience (will be assessed from application form and at interview):


  • Knowledge and understanding of animal physiology
  • Knowledge of molecular and cellular biology
  • Experience with model systems


  • Keen interest in developing skills and experimental methods and cardiac physiology
  • Knowledge of statistical methods in molecular biology and physiology

Personal skills/behaviours/qualities (will be assessed at interview):


  • High level of motivation and drive
  • Evidence of ability to organise and conduct complex research projects
  • Good written and verbal communication skills in English
  • Ability to work effectively with researchers from different fields (computer scientists to experimental biologists) ranging from postgraduate students to professorial level
  • Ability to work both independently and as part of a team
  • Ability and eagerness to learn new concepts and acquire new skills in biology quickly, and to seek novel and creative solutions to scientific problems
  • Willingness to share knowledge and skills with other members of the group on a daily basis.

Upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification).
The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

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