The Duke-NUS Centre for Vision Research and the research team of Prof. Jonathan Crowston offers an exciting opportunity for a Research Fellow in the field of translational neurobiology. The current project goal is to elucidate the ageing-related molecular mechanisms that predispose to glaucoma, a common neurodegeneration affecting ~80 million patients worldwide. The overall goal of the Crowston Lab is to develop clinically translatable neuroprotective strategies for glaucoma focusing on the intersection of aging and injury on neuronal and glial health. The Crowston Lab is well-established with a proven track record of taking treatments from bench-to-bedside.
A motivated and highly qualified Research Fellow will lead a high impact project to identify novel therapeutic approaches that tackle age-related changes in the retina and optic nerve. Specifically, the Fellow will develop a program in which the interactions between injured neurons and associated astroglial populations will be elucidated. The Fellow will work principally on established and new cell culture models (e.g neuroglial metabolic interactions) and established rodent neurorecovery models. Our overarching goal is to find novel therapeutic targets for protecting retinal ganglion cells from glaucoma.
The Duke-NUS Centre for Vision Research brings together the synergies of strength and capabilities bridging neuroscience at Duke-NUS and translational ophthalmology at the Singapore Eye Research Institute. The hired applicant will have the chance to interact and work in an international environment with multidisciplinary basic research scientists, clinicians, and research clinicians.
Please see also: www.crowstonlab.comhttps://www.crowstonlab.com and https://www.duke-nus.edu.sg/directory/detail/crowston-jonathan-guy for more information on projects and access to relevant primary literature.
The major responsibilities and duties will include but are not limited to the following:
- Investigate the impact of advancing age and on retinal ganglion cells and their interactions with astrocytes and Müller cells (a specialised glial cells in the retina) using cutting edge techniques such as stem cell differentiation, microfluidic co-culture, single cell transcriptomics, flow cytometry
- Design, conduct refine, troubleshoot experiments using cell culture models and complimentary rodent studies,
- Assist the Principal Investigator in developing and completing a research grant to springboard future collaboration and build their own future independent research program,
- Assist the PI in the mentoring of PhD students in the research team,
- Conduct accurate monitoring, documenting, analysis and reporting of experimental results and/or research findings,
- Develop and deliver oral presentations or written reports/ scientific manuscripts/literature for publication,
- Performing other related duties incidental to the work described herein.
- PhD in neuroscience, biomedical sciences or other related fields.
- Possess knowledge of laboratory techniques specifically cell and molecular biology techniques such as cell culture, stem cell differentiation, immunohistochemistry, microscopy, DNA/RNA characterisation and biochemical techniques
- Prior practical experience with stem cell differentiation, cell isolation and co-culture, advanced molecular biology techniques, and/or bioinformatic techniques would be advantageous.
- Proven track record in the form of high impact publications.
- Demonstrated capability of research independence progressively
- Has strong writing and critical thinking skills, as well as good communication and presentation skills.
- A team player who is able to prioritise, multi-task and work collaboratively in a diverse workforce.
We regret that only shortlisted candidates will be notified.
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