Vacancy Type/Job category
£29,301-£38,183 per annum
The University of Warwick - Coventry
Fixed term for 36 months
Funding at level 6 (£29,301 - £38,183) is available for a maximum of 36 months; this might have to be shortened up to a maximum contract length of 32 months depending on the starting salary of the successful candidate.
An exciting opportunity exists for an enthusiastic and committed individual to join the research groups of Dr Keith Leppard and Dr Daniel Hebenstreit to carry forward a collaborative project recently funded by MRC.
Innate immunity and inflammation are crucial first lines of defense against pathogens. Specific patterns of gene expression are triggered upon pathogen sensing and we have shown that this gene expression is dependent on an isoform of the promyelocytic leukemia (PML) protein. Equally, aberrant or sustained inflammation is harmful, being a significant cause of chronic disease. In this project, we will use transcriptomics, proteomics, ChIP-seq and directed mutagenesis to investigate the mechanism of PML action in innate immune and inflammatory responses.
You will have a PhD in a relevant discipline and have good knowledge and practical experience in mammalian molecular cell biology as evidenced by your PhD thesis and/or authored papers in peer-reviewed journals. Practical experience in any of the following areas would be an advantage but is not essential: innate immunity, inflammation, virology or PML protein research. Training in bioinformatics analysis will be given.
Please include a full CV, a covering letter and the names of at least 2 referees with your application form. Within this documentation, you should explain how your skills meet the requirements, what you can bring to the post and why the post interests you.
If you have not yet been awarded your PhD but are near submission or have recently submitted your PhD, any offers of employment will be made as Research Assistant on level 5 of the University grade structure (£28,453 pa). Upon successful award of your PhD and evidence of this fact, you will be promoted to Research Fellow on the first point of level 6 of the University grade structure (£29,301 pa).
Interview date - mid-late June 2017
Undertake research in order to support the work of the School and develop and enhance its reputation, both internally and externally. Assist the Project Leaders and, where appropriate, project collaborators in the development and successful execution of the project.
Duties and Responsibilities
• To undertake laboratory-based research to understand the contribution of human PML protein to innate immune and inflammatory responses.
• To be responsible for the accurate conduct and reporting of experimental setup and data, quantitative data analysis and the preparation of results for publication.
• To develop (with the Project Supervisors) research strategies to deliver the project aims and objectives.
• To continually update own knowledge and understanding in fields relevant to the project and to translate knowledge of advances in the subject area into research activity.
• To communicate with collaborators both at Warwick and elsewhere as required.
• To attend and present findings at regular research team meetings, internal seminars and external conferences.
• To publish research outcomes in appropriate journals of international standing and to publish and disseminate the result of research to other reputable outlets.
• To respect and ensure protection of Intellectual Property developed within the project and by the research groups involved with the project.
• To ensure compliance with Health and Safety in all aspects of work.
• To order supplies needed for the project, working within budget constraints.
• To support the development of other research projects and new project proposals through collegiate activities within the research groups of the project supervisors, the School and elsewhere.
• To contribute to the Outreach / Public Understanding activities associated with the project.
• To contribute as required to preparing proposals and applications to external bodies, e.g. for funding and contractual purposes, to support a developing research agenda.
• To contribute as required to the preparation of papers for and the presentation of information on research progress and outcomes to bodies supervising research, e.g. steering groups.
TEACHING AND LEARNING SUPPORT
• Assist in the supervision of student projects and the development of student research skills.
• May be expected to contribute in other ways, by agreement, to the teaching and learning programmes in the School.
ADMINISTRATION AND OTHER ACTIVITIES
• May be required to attend School meetings and to participate (where necessary) in other committees and working groups within the department, the Faculty and the University.
• To comply with all policies and codes of conduct of the University.
The duties and responsibilities outlined are not intended to be an exhaustive list but provide guidance on the main aspects of the job. You will be required to be flexible in your duties.
The Person Specification focuses on the knowledge, skills, experience and qualifications required to undertake the role effectively. This is measured by (a) Application Form, (b) Test/Exercise, (c) Interview, (d) Presentation.
Essential Criteria 1
Good honours degree and possession of a PhD or equivalent in relevant discipline. a)
Essential Criteria 2
Excellent knowledge of mammalian molecular cell biology. a), c), d)
Essential Criteria 3
Good level of practical experience of molecular cell biology techniques. a), c), d)
Essential Criteria 4
Sufficient breadth or depth of specialist knowledge in the discipline and of research methods and techniques to work within established research programmes. a), c)
Essential Criteria 5
Proven ability in research and evidence of quality research output in relevant field. a), c)
Essential Criteria 6
A developing research profile with the ability to publish and/or produce high quality research output. a), c)
Essential Criteria 7
Good effective communication (oral and written) skills, presentation and training skills a), c), d)
Essential Criteria 8
Ability to work independently and as part of a team on research programmes c)
Essential Criteria 9
Practical experience in any of the following: innate immunity, inflammation, virology, PML protein research a), c)
Desirable Criteria 1
Ability or potential to contribute to the development of funding proposals in order to generate external funding to support research projects. c)
For further information about the University of Warwick, please read our University Further Particulars .
For further information about the department, please visit the departmental website .
Dr Leppard (PI) will advise the PDRF in all wet biology work while Dr Hebenstreit (Co-I) will lead on the implementation and analysis of RNAseq and ChIPseq experiments. The research team (PI, Co-I, PDRF plus bioinformatics support) will integrate closely, holding regular bi-weekly progress update and objective-setting meetings, and 6-monthly in-depth half-day discussions on the direction of the work. The University of Warwick provides an outstanding collaborative research environment with cutting-edge technical support. This environment, together with the breadth of expertise of the PI/Co-I team, will give the PDRF appointed to carry out the work excellent support for their intellectual development and provide training in any techniques with which they are unfamiliar.
The project provides an excellent training opportunity at the interface between wet biology and bioinformatics which is key to modern biomedical research. It is intended that the successful applicant will, through their work in the post, gain considerable new technical and analytical experience in a key area. They will also gain transferable skills in science communication, research planning and administration.
The successful candidate must be able to start the position by the latest date of 3rd October 2017
For further information about the background to the project, please visit Dr Leppard's laboratory web pages http://www2.warwick.ac.uk/fac/sci/lifesci/people/kleppard/ and the dedicated web page for this project: http://www2.warwick.ac.uk/fac/sci/lifesci/research/kleppard/research/pmlproject .
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