Full time, fixed term position for up to 34 months.
Research Fellow – Development of synthetic probes for polyketide synthase enzymology
You will carry out laboratory-based research on illuminating and exploiting programmed O-methylation in trans-AT polyketide synthases. You will develop strategies for trapping O-methylating submodules in defined conformational states, to facilitate structure elucidation using single particle cryo-EM and/or X-ray crystallography and investigate the -hydroxy thioester substrate tolerance of trans-AT PKS O-methyl transferase domains. To meet these objectives, you will synthesise diverse pantetheine thioesters, prepare proteins for crosslinking and enzyme activity assays, and carry out intact protein mass spectrometry. The work will be carried out under the joint supervision of Profs Greg Challis and Józef Lewandowski in the Department of Chemistry at the University of Warwick.
You will be a PhD graduate (or will have submitted your thesis prior to commencing) with an outstanding record of accomplishment and strong motivation to become a future research leader. You will be an experienced synthetic chemist with an enthusiasm for addressing important biological questions and will be receptive to developing new skills in protein mass spectrometry and structural biology.
You will be an excellent communicator capable of working effectively both independently and as part of a multidisciplinary team of researchers. You will possess excellent planning and time management skills. You will assist in the supervision of research students, in addition to ensuring your own research objectives are achieved effectively. You will prepare monthly presentations and regular written reports detailing your research progress, and will participate in the preparation of research papers and progress reports. You will present your research results at regular progress meetings, as well as at national and international conferences.
If you have not yet been awarded your PhD but are near submission or have recently submitted your PhD, any offers of employment will be made as Research Assistant on level 5 of the University grade structure (£30,497). Upon successful award of your PhD and evidence of this fact, you will be promoted to Research Fellow on the first point of level 6 of the University grade structure (£31,406 pa).
For informal enquiries please contact:
Professor Greg Challis (firstname.lastname@example.org ); phone +44 24 76574024
Professor Józef Lewandowski (email@example.com ); phone +44 24 76524375
Full details of the duties and selection criteria for this role can be found in the vacancy advert on the University of Warwick’s jobs pages. You will be routed to this when you click on the Apply button.
Research Fellow (104806 0122) , University of Warwick, United Kingdom, about 23 hours ago
Vacancy Type/Job category Research Only Department School of Modern Languages and Cultures Sub Department Hispanic Studies Salary £31,406-£40,927 per annum Location University of Warwick, Coventry...
Clinical Research Fellow (79116 0122) , University of Warwick, United Kingdom, about 23 hours ago
Vacancy Type/Job category Clinical & Medical Department Warwick Medical School, Biomedical Cell Biology Salary £35,155 - £50,025 per annum Location University of Warwick Vacancy Overview Full-time...
Senior Research Fellow (Cct Manufacturing) (72319 1221) , University of Warwick, United Kingdom, about 23 hours ago
Vacancy Type/Job category Research Only Department WMG Salary £42,149 - £50,296 per annum Location University of Warwick Vacancy Overview Full time, Fixed term contract until 31/03/2023 WMG is a v...
Job Search Assistant (101847 0122) , University of Warwick, United Kingdom, about 23 hours ago
Vacancy Type/Job category Clerical Department Education - Student Opportunity Salary £22,847 - £26,341 per annum Location University of Warwick, Coventry Vacancy Overview Permanent position, 36.5 ...
Research Fellow (104931 0122) , University of Warwick, United Kingdom, about 23 hours ago
Vacancy Type/Job category Research Only Department Statistics Salary £31,406 - £40,927 per annum Location University of Warwick, Coventry Vacancy Overview Fixed Term Contract until 31/10/24, 36.5 ...
Research Fellow (105047 0122) , University of Warwick, United Kingdom, about 23 hours ago
Vacancy Type/Job category Research Only Department Politics & International Studies Sub Department IERG Salary £31,406 - £40,927 per annum, pro rata Location University of Warwick, Coventry Vacanc...