Research Fellow (104699-1021)

Updated: about 2 months ago
Location: Coventry, ENGLAND
Job Type: FullTime
Deadline: 28 Nov 2021

Full time, fixed term position for up to 34 months.

Research Fellow – Development of synthetic probes for polyketide synthase enzymology

You will carry out laboratory-based research on illuminating and exploiting programmed O-methylation in trans-AT polyketide synthases. You will develop strategies for trapping O-methylating submodules in defined conformational states, to facilitate structure elucidation using single particle cryo-EM and/or X-ray crystallography and investigate the -hydroxy thioester substrate tolerance of trans-AT PKS O-methyl transferase domains. To meet these objectives, you will synthesise diverse pantetheine thioesters, prepare proteins for crosslinking and enzyme activity assays, and carry out intact protein mass spectrometry. The work will be carried out under the joint supervision of Profs Greg Challis and Józef Lewandowski in the Department of Chemistry at the University of Warwick.

You will be a PhD graduate (or will have submitted your thesis prior to commencing) with an outstanding record of accomplishment and strong motivation to become a future research leader. You will be an experienced synthetic chemist with an enthusiasm for addressing important biological questions and will be receptive to developing new skills in protein mass spectrometry and structural biology.

You will be an excellent communicator capable of working effectively both independently and as part of a multidisciplinary team of researchers. You will possess excellent planning and time management skills. You will assist in the supervision of research students, in addition to ensuring your own research objectives are achieved effectively. You will prepare monthly presentations and regular written reports detailing your research progress, and will participate in the preparation of research papers and progress reports. You will present your research results at regular progress meetings, as well as at national and international conferences.

If you have not yet been awarded your PhD but are near submission or have recently submitted your PhD, any offers of employment will be made as Research Assistant on level 5 of the University grade structure (£30,497). Upon successful award of your PhD and evidence of this fact, you will be promoted to Research Fellow on the first point of level 6 of the University grade structure (£31,406 pa).

For informal enquiries please contact:

Professor Greg Challis (g.l.challis@warwick.ac.uk ); phone +44 24 76574024

Professor Józef Lewandowski (j.r.lewandowski@warwick.ac.uk ); phone +44 24 76524375

Full details of the duties and selection criteria for this role can be found in the vacancy advert on the University of Warwick’s jobs pages. You will be routed to this when you click on the Apply button.


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