Research Associate - Synthetic and Biological Chemistry (Fixed Term)

Updated: 11 months ago
Location: Cambridge, ENGLAND
Job Type: Permanent
Deadline: 18 Sep 2019

Fixed-term: The funds for this post are available for 1 year in the first instance.

Applications are invited for a post-doctoral research associate to join the group of Dr Bernardes at the Department of Chemistry, University of Cambridge to work on the ERC Proof of Concept project named "LapIt". The role is to design and apply new methods that focus on a specific drug to act as an antibody-drug conjugate that targets a particular mechanism in the treatment of acute myeloid leukemia.

The successful candidate will perform reaction engineering in aqueous solution to apply in the context of site- selective antibody conjugation, linker design and synthesis, and construction and characterisation of antibody- drug conjugates both in vitro and in cells. This will consist of reaction optimisation and synthesis of suitable reagents, design and synthesised suitable intracellular cleavable linkers, build antibody-drug conjugates, purify and characterise (mass spectrometry and biophysical measurements such as SPR and CD), and test for activity in relevant cell lines.

The successful candidate will have (or be about to obtain) a PhD in chemical biology/synthetic chemistry. They will be highly motivated and able to work independently. Excellent organisational and interpersonal skills are required to ensure success in liaising with a large and diverse research team. Previous experience with antibody conjugation and characterisation of conjugates by advanced mass spectrometry and testing in relevant cell lines is desirable.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

Further details about the post can be obtained from Prof Ernest Laue ( or Prof. Dave Klenerman ( ).

Please quote reference MA20346 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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