Research Associate - Single molecule imaging of neuroinflammation (Fixed Term)

Fixed-term: The funds for this post are available for 2 years in the first instance.

A postdoctoral position is available working on a collaborative project between the group of Professor Clare Bryant (Medicine) and the group of Sir David Klenerman FMedSCi FRS. This is a part of a multidisciplinary project based in the Department of Chemistry.

Dementia is the biggest health challenge of our century. The project aims to explore the molecular mechanisms by which low concentrations of protein aggregates cause increasing inflammation in glial cells over time, via triggering of Toll-like receptors. The applicant will produce and characterize protein aggregates and then apply these aggregates to in vitro macrophage models where the Myddosome or Triffosome has been tagged to directly visualize early signaling events using fluorescence imaging (see https://elifesciences.org/reviewed-preprints/92350/figures and https://elifesciences.org/articles/3137

Applicants should have (or be about to obtain) a PhD in a relevent specialist area. Experience of single molecule fluorescence imaging, building and working with home-built instrumentation and it is essential that they have prior experience of cell culture and imaging of cells. Experience of studying cellular neuroinflammation or oxidative stress is also required. Funding is for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries relating to your application or the application process, please contact [email protected] .

Please quote reference MA40732 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information
Apply online