Research Associate in Cellular Neuroscience and iPSCs

Location: White City Campus

Job Summary

The Ye lab invites applications from talented, highly motivated, and ambitious postdoctoral scientists for a Research Associate position leading one or more projects exploring the role of proteasomes in the clearance of toxic aggregates derived from pathological samples. The project will unveil factors that assist proteasomes in removing amyloidogenic proteins in healthy cells and the malfunction of proteasomes in pathological cells. You will use a multidisciplinary approach (maintenance and manipulation of IPSC-neurons and established cell lines, fluorescence imaging and various biochemical techniques) to identify the types of modifications and potential factors that are associated with proteasomes during cell stress induced by pathological protein aggregates.

Please contact Dr Yu Ye – [email protected] for a discussion about the project and role.

This role is part of the Department of Brain Sciences at Imperial College London , located in.  Postdocs in the Ye lab at Imperial enjoy excellent career development opportunities with:

• Access to a range of cutting-edge technologies for 2D and 3D super-resolution imaging capabilities
• Dedicated iPSC culture facilities in the new state-of-the-art Sir Michael Uren Hub.
• A collegial, team-oriented working environment.
• National links with colleagues in the UK DRI and international links with colleagues at Harvard Medical School.
• Support from the Postdoc and Fellows Development Centre (PFDC ) and Imperial and UK DRI ECR Communities
• The opportunity to mentor, supervise and teach students

Duties and responsibilities

As a Research Associate in the Ye lab, you will:

• Build on your existing skills and experience to address major components of this project independently.
• Present research findings as written reports, at conferences, within the College and as published manuscripts.
• Take initiative in the planning of research, with clear and timely communications to the Group Leader and relevant researchers.
• Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students.
• Provide guidance to staff and assist in the supervision of undergraduate and postgraduate research students, as required.
• Maintain highly organised and accurate records of experimental work.
• Undertake appropriate scientific and professional training.

Essential requirements

You are a motivated and organised researcher, excited by the science we do.

With (or near completion of) a PhD in Cellular Neuroscience and/or IPSC cultures (or related discipline), you will be strongly objective-driven, able to lead the project independently and put new knowledge into practice effectively.

Experimental expertise working with IPSC-differentiated neuronal culture, basic biochemistry and molecular biology is essential. Experience with advanced microscopy is a bonus.

Practical experience of quantitative image analysis, mass spectrometry or coding research projects is highly desirable in the lab.

Further Information

This position is offered full or part time, up to three-years and is based at the White City.

Applicants who have not yet had their PhD degree awarded will be appointed to the Research Assistant scale.

For issues related to the online application, please contact [email protected]

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.