School of Medicine
Research Associate (Human Cell Biology)
Division of Psychological Medicine and Clinical Neurosciences
Cardiff University School of Medicine
College of Biomedical and Life Sciences
The MRC Centre for Neuropsychiatric Genetics and Genomics and the Neuroscience and Mental Health Research Institute have recently formed a new drug discovery collaboration with Takeda Pharmaceutical Company Limited to identify new approaches for treating schizophrenia and other psychiatric disorders. The partnership will combine the University’s large-scale genomic data and world-class expertise in psychiatric genetics, genomics, clinical and basic neuroscience with Takeda’s extensive drug discovery and clinical development capabilities.
As part of this exciting academic-industrial alliance we require a Research Associate to conduct research relating to the testing and validation of new compounds and signaling pathways for the treatment of neuropsychiatric disorders on 3D cultured adult human neural cells and tissues in vitro. You should hold a Postgraduate degree at PhD level (completed and submitted) in a related subject area and/or relevant industrial experience. You will be a confident communicator, with the ability to demonstrate creativity, innovation and team-working.
This post is full time (35 hours per week), available immediately and is fixed term for 3 years.
Salary: £33,199 - £39,609 per annum (Grade 6)
Date advert posted: Monday, 18 February 2019
Closing Date: Thursday, 21 March 2019
Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.
Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.
To conduct research relating to the testing and validation of new compounds and signalling pathways for the treatment of neuropsychiatric disorders on 3D cultured adult human neural cells and tissues in vitro. To contribute to the overall research performance of the School and University, carrying out research leading to the publishing of work in high-quality journals and to pursue excellence in research, inspiring others to do the same.
Main Duties and Responsibilities
• To conduct research relating to the testing and validation of new compounds and signalling pathways for the treatment of neuropsychiatric disorders on 3D cultured adult human neural cells and tissues in vitro.
• To generate and maintain human adult neural 3D cultures from fresh neurosurgical tissue and from hES derived cells and combinations thereof.
• To develop paradigms for testing novel drug and mechanistic signalling pathways on these tissues using a range of techniques including patchclamp electrophysiology, immunohistochemistry, live cell imaging, and morphological and molecular biological analyses.
• To contribute to the overall research performance of the School and University by the production of measurable outputs including bidding for funding, publishing in national academic journals and conferences, and the recruitment and supervision of postgraduate research students.
• To develop research objectives and proposals for own or joint research including research funding proposals.
• To attend and or present at conferences/seminars at a local and national level as required.
• To undertake administrative tasks associated with the research project, including the planning and organisation of the project and the implementation of procedures required to ensure accurate and timely reporting.
• To prepare research ethics and research governance applications as appropriate.
• To review and synthesise existing research literature within the field.
• To participate in School research activities.
• To build and create networks both internally and externally to the University, to influence decisions, explore future research requirements, and share research ideas for the benefit of research projects.
• To engage effectively with industrial, commercial and public sector organisations, professional institutions, other academic institutions etc., regionally and nationally to raise awareness of the School’s profile, to cultivate strategically valuable alliances, and to pursue opportunities for collaboration across a range of activities. These activities are expected to contribute to the School and the enhancement of its regional and national profile.
• To undergo personal and professional development that is appropriate to and which will enhance performance.
• To participate in School administration and activities to promote the School and its work to the wider University and the outside world.
• Any other duties not included above, but consistent with the role.
Qualifications and Education
1. Postgraduate degree at PhD level (completed and submitted) in a related subject area or relevant industrial experience.
Knowledge, Skills and Experience
2. An established expertise and proven portfolio of research and/or relevant industrial experience as follows:
i. Expertise in whole cell patch clamp electrophysiology of interneuron and principle cell precursors.
ii. Experience of and ability to culture adult human brain tissue in 3D on air-fluid liquid interface models and co-culture these with hES derived cells.
iii. Expertise in immunohistochemistry and confocal imaging of adult human neural 3D cultures.
iv. Experience in culturing and deriving interneurons and principle cells from human ES cells
3. Knowledge of current status of research in specialist fields, as noted in (2) above.
4. Proven ability to publish in high-quality journals.
5. Knowledge and understanding of competitive research funding to be able to develop applications to funding bodies.
Communication and Team Working
6. Proven ability in effective and persuasive communication.
7. Ability to supervise the work of others to focus team efforts and motivate individuals.
8. Proven ability to demonstrate creativity, innovation and team-working within work.
9. Experience of single Na+ channel unit recording.
10. Evidence of collaborations with industry.
11. Proven ability to adapt to the changing requirements of the Higher Education community.
12. Evidence of ability to participate in and develop both internal and external networks and utilise them to enhance the research activities of the School.
IMPORTANT: Evidencing Criteria
It is School of Medicine's policy to use the person specification as a key tool for short-listing. Candidates should evidence that they meet ALL of the essential criteria as well as, where relevant, the desirable. As part of the application process you will be asked to provide this evidence via a supporting statement.
Please ensure when submitting this document / attaching it to your application profile you name it with the vacancy reference number, in this instance for this post, 8201BR
If candidates do not provide written evidence of meeting all of the essential criteria then their application will not be progressed. The School of Medicine welcome the submission of CVs to accompany evidence of the job-based criteria.
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