A postdoctoral Research Associate position is currently available for an individual to work in the laboratory of Dr Cedric Ghevaert within the Department of Haematology and Cambridge Stem Cell Institute (CSCI) (https://www.stemcells.cam.ac.uk/People/pi/ghevaert ).
You will be joining a group working at the forefront of research into the production of blood cells for human use. Building on an outstanding track record of research in the production of red cells and platelets from human pluripotent stem cells (e.g. Moreau et al Nat Commun 2016) and the use of 3-dimensional bioreactors (e.g. Shepherd, J et al, Biomaterials 2018), we are developing techniques for the affordable mass production of these cells at clinical grade.
The successful candidate will undertake a project focused around megakaryopoiesis and platelet biogenesis from human pluripotent stem cells. In particular, you will be creating a library of genome-edited cell lines that have been modified in order to study particular pathways that are responsible for platelet formation in vivo and in bespoke bioreactors. The cells will be differentiated into megakaryocytes and the platelet formation will subsequently be studied in collaboration with the team of Prof Poole (University of Bristol).
The successful candidate will have a PhD, considerable experience in stem cell biology, molecular biology and a keen interest in clinical application. These will be supported by a proven track record in scientific publications. Prior experience in mammalian cell culture is essential. Experience of genome editing is highly desirable alongside experience of supervising and training junior colleagues. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have good presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers. The ability to establish and foster collaboration is essential given the multi-centre nature of the project.
The Wellcome - MRC Cambridge Stem Cell Institute (CSCI) is a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology. https://www.stemcells.cam.ac.uk/ . Informal enquiries should be directed to Dr Cedric Ghevaert (firstname.lastname@example.org )
Fixed-term: The funds for this post are available for 12 months in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.
The closing date for applications is 06 October 2020, with interviews expected to take place on 19 October 2020.
Please quote reference RB23995 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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