Research Associate (Fixed Term)

Updated: about 1 month ago
Location: Cambridge, ENGLAND
Job Type: FullTime
Deadline: 30 Sep 2021

Investigating Alpha1-antitrypsin phase transition in the endoplasmic reticulum

We are seeking a post-doctoral research associate to join the Marciniak lab in CIMR to study the role of protein phase transitions in alpha1-antitrypsin deficiency. The Alpha1-Foundation-funded post is at research associate (post-doc) level and so a PhD in a relevant discipline and expertise in mammalian cell culture are essential. Experience in proteomics, flow cytometry, confocal microscopy or stem cells would be advantageous but not essential as training can be provided.
The Marciniak lab combines cell biology, biochemistry, and translational medicine to understand the role of proteotoxicity in human disease ( ). The successful applicant will use a variety of cutting-edge microscopy and proteomics techniques to understand the effects of protein phase transitions on function of the endoplasmic reticulum of iPSC-derived hepatocytes.

Recent relevant papers include

Ordonez A, Harding HP, Marciniak SJ, Ron D (2021). Cargo receptor-assisted endoplasmic reticulum export of pathogenic alpha1-antitrypsin polymers. Cell Reports doi: 10.1016/j.celrep.2021.10914
Chambers JE, Kubankova M, Huber, R, López-Duart I, Avezov E, Bond P., Marciniak SJ*, Kuimova, M* (2018) An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles. ACS Nano 12:4398-4407. *Joint senior
Holcman D, Parutto P, Chambers JE, Fantham M, Young LJ, Marciniak SJ, Kaminski CF, Ron D, Avezov E. (2018). Single particle trajectories reveal active endoplasmic reticulum luminal flow. Nat Cell Biol 20:1118-1125 doi: 10.1038/s41556-018-0192-2.

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit : .

Please contact Professor Stefan Marciniak at  and Dr Joe Chambers at  for further information.

Please quote reference SC27376 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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