We are pleased to advertise a post for a Postdoctoral Researcher to study the composition and role of tricellular adherens junctions in epithelial morphogenesis in Dr Bénédicte Sanson's group.
We have discovered the first known resident component of tricellular adherens junctions (tAJs) in the fruit fly Drosophila, the transmembrane adhesion molecule Sidekick (Sdk) [1,2]. Sidekick, and thus tAJs, have been shown to be important in various aspects of epithelial morphogenesis in several tissues in Drosophila. We propose here to elucidate how Sidekick localises at tAJs and to understand better Sidekick's role in facilitating cell rearrangements during the extension of the main body axis in fly embryos. Approaches for the project will include molecular dissection of Sdk, optogenetics and super-resolution microscopy, the latter in collaboration with Prof. Daniel St Johnston (Gurdon Institute) and the Cambridge Advanced Imaging Centre. There will also be an opportunity to collaborate with Dr Clare Buckley (PDN) to address the conservation of this epithelial role of Sdk in vertebrates, in the zebrafish model.
The approaches developed for this project will complement and synergise with existing approaches in the lab, including Drosophila genetics, advanced live imaging, computational analysis of cell behaviours and mathematical modelling. This is an opportunity for a motivated researcher with expertise in molecular biology and imaging to join a multi-disciplinary team.
Funding for the project is for 2 years in the first instance, with a preferred start in September 2021, and fellowship applications will be encouraged.
 Finegan TM, Hervieux N, Nestor-Bergmann A, Fletcher AG, Blanchard GB, Sanson B. (2019) The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension. PLoS Biol. doi: 10.1371/journal.pbio.3000522.  Lye CM, Naylor HW, Sanson B. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development. doi: 10.1242/dev.111310.
We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.
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To apply, please refer to the Further Particulars and use these as a guideline for your application. Applications must be received by the deadline of 20th August 2021. We intend to hold Zoom interviews for shortlisted candidates in early September 2021.
Please quote reference PM26973 on your application and in any correspondence about this vacancy.
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