Research Assistant

Updated: 2 months ago
Location: Harwell, ENGLAND
Job Type: FullTime
Deadline: 09 Mar 2021

Fixed Term until 31 March 2022

About the Role

We have an exciting opportunity to join The Mary Lyon Centre at the Medical Research Council Harwell where you will provide technical support to a busy Genome Engineering service team.

You will be based within established laboratories involved in the generation and quality control of mouse targeted alleles and genotyping. You will work as part of a team and be responsible for performing a range of Molecular Biology techniques (including generation of CRISPR reagents, PCR, Sanger and long-read sequencing analysis, digital droplet PCR, non-radioactive Southern blotting and qPCR-based genotyping) and embryonic stem (ES) cell culture. Emphasis on particular techniques will vary according to service demand.

Main duties / key responsibilities:

Characterisation and quality control of genetically modified materials employing high end PCR-based techniques and non-radioactive Southern blotting. Genotyping. Sample management and communication of results. Some ES cell culture.

About you

As the successful candidate you will have a BSc in Biological Sciences or related including an understanding of genome engineering techniques in animal models (gene targeting, CRISPR-based tools). You will have proven experience of wworking in a molecular biology laboratory, using techniques such as PCR, qPCR and cloning.

Attention to detail is essential for this role as you will need to demonstrate extensive experience in handling and analysing complex sequencing datasets. You will have excellent communication skills, be customer focused and be able to produce work at a high standard.

The role requires you to be, computer literate for the recording and communication of results. Previous experience with DNA sequence analysis software is essential.

About us

MRC Harwell Institute is an international biological research centre at the forefront of the use of mammalian models to study genetics and human diseases. Located on the Harwell Campus, just south of Oxford, it is nestled amongst a vibrant community of leading science organisations. We aim to advance medicine through cutting-edge research into the genetic basis of disease. Our research programmes span an entire lifetime, from embryonic development to diseases of ageing. There are over 300 staff at the Institute made up of research scientists, technicians, animal carers, and business support personnel.


Choosing to come and work at the MRC (part of UKRI) means that you will have access to a whole host of benefits including 30 days annual leave per year + 10.5 public and privilege days, a defined benefit pension scheme and access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. You will also get the chance to put the MRC and UKRI on your CV in the future.

How to apply

For full details of this post view:  to complete an online application. Please include a cover letter describing your motivation for applying. Please quote reference number MLC 1469

Closing Date: 9th March 2021

View or Apply

Similar Positions