Research Assistant in Structural Biology of Chromatin

We have an exciting opportunity for a talented researcher to investigate fundamental questions of gene regulation and chromatin modifications. The post of Research Assistant is funded by the BBSRC to investigate the mechanism of histone H2B ubiquitylation in the promotion of euchromatic domains. The successful candidate will join a vibrant community with a strong focus on transcription and chromatin at the University of Leicester’s Department of Molecular and Cell Biology and will be based in the research group of Prof Thomas Schalch, which has a long-standing interest in structural and functional understanding of chromatin. The Research Assistant will be a member of the Leicester Institute for Structural and Chemical Biology (LISCB), a centre of research excellence initiated by the University of Leicester, which provides access to state-of-the-art integrated structural biology facilities comprising cryo-electron microscopy, X-ray crystallography and biomolecular nuclear magnetic resonance (NMR). LISCB hosts a Titan Krios G3, 600 and 800 MHz Bruker NMR spectrometers with cryo-probes, a Rigaku X-ray diffraction system, multiple robotic systems for preparing crystal screens, excellent computer facilities and a range of HPLC and FPLC protein chromatography systems. Dedicated computing facilities and senior cryo-EM and computational experimental officers support the project.

Primary Supervisor: Prof Thomas Schalch, University of Leicester, UK

The ideal candidate will have strong experience in protein expression in bacteria and insect cells, protein purification, biochemical characterization and knowledge of cryo-EM structural analysis. A high level of proficiency in English and excellent written and verbal communication skills are essential requirements for this position.

Informal enquiries are welcome and should be made to Prof Thomas Schalch on [email protected].