Research Assistant in Proteomics LMS 1396

Updated: 21 days ago
Location: London, ENGLAND
Deadline: 08 Nov 2020

View Vacancy -- Research Assistant in Proteomics LMS 1396
Open Date
06/10/2020, 13:00
Close Date
08/11/2020, 23:55

MRC London Institute of Medical Science

The LMS is an Institute funded by the MRC and is a Division of the Faculty of Medicine, Imperial College. Based on the Hammersmith Hospital Campus in West London (W12), the LMS has first class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the established clinical base of Imperial College. For more information, visit .
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 5


£30,277 - £31,930 pa (inclusive of allowances)


Fixed Term


Full Time

3 years

Overall Purpose:

Support the work of the Proteomics core facility to provide advanced technology and expertise to the MRC London Institute of Medical Sciences for the analysis of complex biological samples.


Main Duties:

  • Sample preparation of biological protein samples prior to analysis by liquid chromatography-tandem Mass Spectrometry (LC-MS).
  • Operation and maintenance of LC-MS systems in the Proteomics facility for the analysis of complex protein samples.
  • Quality control of LC-MS procedures and setting up of analysis methods.
  • Biochemical separations using different types of methods including cell based techniques, chromatography, electrophoresis and centrifugation.
  • Perform data analysis of quantitative Proteomics data sets using specialised software (MaxQuant, Perseus, Progenesis, MASCOT and other in-house software).
  • Develop and apply skills in the bioinformatics analysis of large and complex Proteomics data sets.
  • Be responsible for collaborative projects with MRC LMS research groups involving Mass Spectrometry and Proteomics.
  • Communicate results to the facility head and other project members.
  • Participate in scientific discussions and design of collaborative projects.
  • Record data and report results in agreed formats.
  • Be actively involved in the development of new Proteomics approaches and present work at internal as well as external meetings.
  • Contribute to the general maintenance of the laboratory.


 Key Responsibilities:

  • Design and delivery of Proteomics and Mass Spectrometry workflows within the Proteomics facility.
  • Processing and preparation of Proteomics samples submitted to the facility.
  • Daily operation and maintenance of HPLC systems and tandem Mass Spectrometers.
  • Data analysis and interpretation using computational algorithms and bioinformatic approaches.
  • Record, communicate and report results in agreed formats.

Education, qualifications and training (will be assessed from application form and at interview):


  • Qualified to degree level in chemistry, biochemistry, life sciences, a related discipline or equivalent relevant experience


  • A research-based qualification (MRes or similar)


Previous work experience (will be assessed from application form and at interview):


  • Previous experience in a research laboratory environment in the context of instrumental analysis and mass spectrometry


  • Experience of maintaining liquid chromatography and mass spectrometry systems
  • Previous experience of working with complex protein samples and mass spectrometers


Knowledge and experience (will be assessed from application form and at interview):


  • Very good level of computing skills and an interest in applying bioinformatics analysis approaches to complex data sets
  • Excellent written and verbal communication skills and the ability to interact effectively with facility users and colleagues in the facility


  • Experience of using bioinformatics tools for the analysis of large proteomics data sets (such as MaxQuant, Perseus, MASCOT, Progenesis QI, PEAKS
  • Previous experience of working with research scientists in a collaborative manner and on multiple projects

Personal skills/behaviours/qualities (will be assessed at interview):


  • A skilled experimenter with the ability to generate high quality, reproducible results
  • Good level of organisation and record keeping, careful documentation of procedures and results
  • A desire to gain a high level of understanding of the techniques underlying proteomics (tandem mass spectrometry and liquid chromatography)
  • An interest in biological systems and protein biochemistry
  • Excellent written and verbal communication skills and the ability to interact effectively with facility users and colleagues in the facility
  • Motivated and enthusiastic individual who is conscientious and has the desire to make a significant positive contribution to the facility and the wider institute.
  • The willingness to take responsibility and ownership of the tasks assigned to them. The ability to work as part of a team and in a collaborative manner is a prerequisite.
  • An interest in developing their own skills further and becoming an expert in the fields of mass spectrometry and proteomics are desirable.



Upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification).

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

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