Research Assistant (Fixed Term) (Mendez-Ferrer Lab)

Updated: about 1 month ago
Location: Cambridge, ENGLAND
Job Type: Permanent
Deadline: 15 Nov 2021

We are seeking an enthusiastic full-time Research Assistant to join the group of Prof Simon Mendez-Ferrer within the Haematology Department based on the Cambridge Biomedical Campus ( ). The Mendez-Ferrer lab is focused on the regulation of the haematopoietic stem-cell niche in health and disease. Blood stem cells reside in specialised niches that allow them to self-renew, proliferate, differentiate and migrate according to the organism's requirements. The group has demonstrated that the brain regulates a peripheral stem cell niche in the bone marrow partly through sympathetic innervation of mesenchymal stem cells that share a niche with haematopoietic stem cells. Ageing is associated with an increased risk to develop myeloid malignancies, such as myeloproliferative neoplasms (MPNs) and acute myeloid leukaemia (AML). The group has shown that the remodelling of the bone marrow microenvironment promotes myeloid cell expansion during premature or physiological ageing. Indeed, damage to this niche regulation is required for MPN progression. Neuroendocrine regulation of bone marrow stem cells by adrenergic signals or by sex hormones could potentially offer novel therapeutic approaches in MPN. Furthermore, AML cells co-opt energy sources and antioxidant defence mechanisms from niche-forming mesenchymal stem cells to survive chemotherapy, offering potential adjuvant therapies to decrease AML relapse.

The successful candidate should hold a degree in a biomedical field or equivalent. Prior experience of laboratory-based research and working with laboratory mice and human samples are essential. An understanding of principles of cellular and molecular biology techniques (DNA; RNA and protein extraction; RT, PCR, QPCR, flow cytometry, cell culture, Western Blot) would be preferable.

The successful candidate will be expected to support the research team by providing technical assistance in the research projects and recording data from experiments. You will be expected to plan your own day-to-day research activity, coordinating with other group members to avoid duplication or conflict. You will be offered the possibility to develop your own research project of interest, provided it is compatible with fulfilling other responsibilities, which include a wide range of tasks to ensure the smooth running of the laboratory, including ordering and maintaining laboratory supplies, as well as maintaining and updating protocols and reagent databases.

The closing date for applications is 15 November 2021.

Interviews for the position will take place during week commencing 22 November 2021.

Informal enquiries directed to Prof Simon Mendez-Ferrer, are encouraged.

Fixed-term: The funds for this post are available until 31 May 2024 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference RB28436 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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