Applications are invited for an enthusiastic postdoctoral scientist to join a team investigating neutrophil responses to bacterial infections. The project is funded by an MRC Clinician Scientist grant and will focus on mechanisms of neutrophil phagosome maturation. Dr Conway Morris's group are interested in how neutrophil antibacterial responses are impaired in sepsis (severe infections) and how this relates to outcomes in intensive care units. The project is based on recent findings concerning impaired phagosomal maturation (JCI Insight. 2020 Aug 6;5(15):e137029), how this relates to impairment of the process of LC3-associated phagocytosis and the impact this has on bacterial pneumonia. This work will help with the development of immunomodulatory therapies for sepsis and critical illness.
The position will be held a newly refurbished lab on Tennis Court Road at the Department of Pathology in Cambridge. Dr Conway Morris works closely with Professor Okkenhaug's group, who are interested in immune cell intra-cellular signalling pathways in a number of diseases, and the successful applicant will be expected to contribute to the synergistic collaborations between the groups. The Department is well-resourced and full access to flow cytometry, imaging, sequencing and biological services facilities will be available.
Candidates should be highly motivated, and have a PhD (or equivalent qualification) in a relevant biological science. Ideally, the candidate will have experience working with mouse models, particularly mouse models of infection. Experience in neutrophil biology or more general innate immunity is an advantage, as are skills in flow cytometry or confocal and advanced light microscopy. However, training will be provided as needed.
Where the successful applicant does not yet have a PhD, they will normally be under-appointed as a Research Assistant in a Research Associate post (on the understanding that they will be appointed as a Research Associate upon successful completion of their PhD). The higher Research Associate salary should be backdated to the submission date of their thesis.
The ability to work both independently and as part of a team, coupled with excellent communication, organizational and problem solving skills, attention to detail, and an enthusiasm for scientific research, are required. The duties/responsibilities of this post include developing and driving research objectives, recording and analysing data to prepare research results for presentation/publication, mentoring undergraduate and graduate students, and delivering presentations at lab meetings and wider departmental seminars.
PhD or equivalent in a biological science
Ability to work with mice
Ability to work as part of a team
Research experience evidenced by data published in peer-reviewed journal
Research experience evidence by first author peer-reviewed publications or publicly deposited pre-prints
Home office personal licence (PIL)
Experience with mouse models of infection
Experience with Flow Cytometry or confocal and advanced light microscopy
Experience with in neutrophil or innate immune cell biology
The closing date is August 5th 2021. Interviews are expected to take place in the week of the 23rd August 2021. The ideal start date is 1st October 2021
Fixed-term: The funds for this post are available until February 2025 in the first instance.
Specific queries may be directed to firstname.lastname@example.org (Dr Conway Morris).
Further reading document attached below
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For further details or informal enquires please contact Jodi Smith via email (email@example.com ).
Please quote reference PK27258 on your application and in any correspondence about this vacancy.
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