Research Assistant/Advanced Research Assistant

An opportunity has arisen for two talented Cell Biologists to support the Cellular Generation and Phenotyping team (CGaP) at the Sanger Institute, a world leader in genome research. You will work across two projects, developing and characterising human organoid models.

About the role

Working in the organoid derivation team in a collaborative environment across two projects, you will develop models from a variety of tissues including female reproductive tissues and human tumour samples.

Your role in CGaP will include:  

• Processing of samples to derive new 3D organoid models
• Expansion and banking of organoids
• Ensuring Quality Controls are met
• Co-ordinate the transfer of samples to and from the faculty team
• Troubleshoot issues and identify areas for process improvement
• Ensure processes and protocols are kept up to date

There may also be the opportunity to work on our cancer organoid CRISPR screening project, performing genome-wide loss of function CRISPR screens to identify novel therapeutic targets.

You will be provided with all the appropriate training for you to fulfil your role. We encourage all staff to take part in the learning and development opportunities available.

About you

• Relevant cell biology experience, including cell culture and cell-based assays
• A keen interest in process improvement
• Excellent team working and communication
• Able to train junior staff (dependent on job level)
• Strong time management

About the research

We are a core research group, responsible for providing cell biology resource and expertise to the wider institute. We do this by running multiple, diverse, high-throughput projects for faculty teams across the Sanger Institute.

Our current portfolio of projects includes genome-wide CRISPR screens of iPSC and cancer cells, differentiation of iPSCs toward neuronal lineages, organoid derivation, iPSC derivation and Spatial Genomics associated with the Human Cell Atlas Initiative. Our role is to support the institute in its aims and for that, we continually strive to remain at the forefront of cutting edge research. Namely translating academic research into large-scale projects, which push the boundaries of our understanding, allowing the Sanger to remain a world leader in genome research.

Please see the attached documents for a full and separate breakdown of the responsibilities and personal specification for each of the below roles. 

Please include a CV and covering letter with your application describing how you meet the essential criteria for the role.

Applications will be considered and reviewed on an ongoing basis and therefore the post may be filled before the closing date.