Principal Bioinformatician/Data Engineer

Updated: about 2 years ago
Location: Cambridge, ENGLAND
Deadline: The position may have been removed or expired!

The Human Genetics Programme at the Wellcome Sanger Institute is driving a step-change in our understanding of genetic causes and biological mechanisms of disease susceptibility and progression, focusing on developmental disorders and diseases of the blood and immune system. We integrate population-scale genetics, longitudinal clinical data, and large-scale genetic perturbation studies in cellular model systems. We aim to transform the clinical utility of human genetic variation.

 Every day, our research groups generate valuable scientific data. Unlocking the full potential of that data involves making it findable, accessible and reusable to the department and the institute as a whole.

 We are looking for a Principal bioinformatician / data engineer to work closely with our diverse research teams and our programme informatics team (HGI) to

  • Gain a pragmatic understanding of the breadth of in-flight projects and historical projects.
  • Drive the design and implementation of a policy to track and annotate Human Genetics group research projects, their data and archival needs.
  • Evaluate, classify and annotate studies, samples and datasets in a way that allows their data to be discovered and re-used.
  • Work with our metadata server by writing code to populate and interrogate its data, and writing automation to maintain its currency.
  • Communicate the utility of the collected data to the research groups, department and institute as needed..

The institute as a whole is exploring solutions to gather high-level management metadata. In addition, some individual research groups are exploring metadata templates to organise their studies. You will be expected to stay abreast of these developments and to work with them as necessary. Success in the role will be measured by

  • The creation of a data management policy guiding HGI and the faculty teams in managing their study data across the study lifecycle.
  • The quality of data in our metadata server, its relevance to existing faculty and their groups, and to the institute.
  • The coverage and currency of data in the metadata server.
  • The interfaces the server presents to the department and the institute.

You will work closely with members of the Human Genetics Informatics and the faculty teams to specify interfaces and collaborate in their implementation.


- Why you would like to work at the Wellcome Sanger Institute in this particular role?

You may wish to consider the criteria set out above and in the job description in your answers.



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